AGPS-IN-1

• 常用名: AGPS-IN-1
• 英文名: AGPS-IN-1
• CAS号: 2316782-88-2
• 分子量: 345.34
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₇F₂N₃O₂
• 熔点: N/A
• 闪点: N/A

AGPS-IN-1用途

AGPS-IN-1(化合物2i)是一种有效的AGPS粘合剂。AGPS-IN-1降低醚脂质水平和细胞迁移率。AGPS-IN-1抑制前列腺PC-3和乳腺MDA-MB-231癌症细胞的上皮-间质转化(EMT)[1]。

AGPS-IN-1名称

• 英文名: Benzenepropanamide, N-[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)methyl]-2,6-difluoro-β-methyl

AGPS-IN-1生物活性

• 描述: AGPS-IN-1(化合物2i)是一种有效的AGPS粘合剂。AGPS-IN-1降低醚脂质水平和细胞迁移率。AGPS-IN-1抑制前列腺PC-3和乳腺MDA-MB-231癌症细胞的上皮-间质转化(EMT)[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Stazi G, et al. Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells. Eur J Med Chem. 2019 Feb 1;163:722-735.

AGPS-IN-1物理化学性质

• 分子式: C₁₈H₁₇F₂N₃O₂
• 分子量: 345.34
• InChIKey: VDLFVZUKOKPJRH-UHFFFAOYSA-N
• SMILES: CC(CC(=O)NCc1ccc2[nH]c(=O)[nH]c2c1)c1c(F)cccc1F

AGPS-IN-1靶点实验

查看更多实验

实验名称：Modulation of epithelial-mesenchymal transition in human MDA-MB-231 cells transfected... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4412557

实验名称：Modulation of epithelial-mesenchymal transition in human MDA-MB-231 cells transfected... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4412558

实验名称：Cytotoxicity against human MeT-5A cells at 250 uM after 24 hrs by MTS assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL4412561

实验名称：Antiproliferative activity against human MDA-MB-231 cells at 250 uM after 24 hrs by M... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4412549

实验名称：Modulation of epithelial-mesenchymal transition in human PC3 cells assessed as upregu... 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL4412550

实验名称：Modulation of epithelial-mesenchymal transition in human MDA-MB-231 cells assessed as... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4412551

实验名称：Modulation of epithelial-mesenchymal transition in human PC3 cells assessed as down r... 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL4412552

实验名称：Modulation of epithelial-mesenchymal transition in human MDA-MB-231 cells assessed as... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4412553

实验名称：Modulation of epithelial-mesenchymal transition in human PC3 cells assessed as down r... 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL4412554

实验名称：Modulation of epithelial-mesenchymal transition in human MDA-MB-231 cells assessed as... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4412555

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