Anticancer agent 11

• 常用名: Anticancer agent 11
• 英文名: Anticancer agent 11
• CAS号: 2332936-95-3
• 分子量: 335.40
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₁N₃O₂
• 熔点: N/A
• 闪点: N/A

Anticancer agent 11用途

抗癌剂11是一种广谱抗癌剂,可抑制血管生成并诱导DNA交联。

Anticancer agent 11名称

• 英文名: Anticancer agent 11

Anticancer agent 11生物活性

• 描述: 抗癌剂11是一种广谱抗癌剂,可抑制血管生成并诱导DNA交联。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> DNA烷基化剂/交联剂
• 参考文献:

  [1]. Chen TL, et al. Discovery of Oral Anticancer 1,2-Bis(hydroxymethyl)benzo[g]pyrrolo[2,1-a]phthalazine Hybrids That Inhibit Angiogenesis and Induce DNA Cross-Links. J Med Chem. 2021 Sep 9;64(17):12469-12486.

Anticancer agent 11物理化学性质

• 分子式: C₂₀H₂₁N₃O₂
• 分子量: 335.40
• InChIKey: XXFGIUPNRLVHBP-UHFFFAOYSA-N
• SMILES: Cc1c(CO)c(CO)c2c3cc4ccccc4cc3c(N(C)C)nn12

Anticancer agent 11靶点实验

查看更多实验

实验名称：Binding affinity to pEGFP-N1 DNA (unknown origin) assessed as induction of cross-link... 来源：ChEMBL 靶标：DNA External Id：CHEMBL4841204

实验名称：Inhibition of human DNA topoisomerase 1 at 100 uM incubated for 30 mins by electropho... 来源：ChEMBL 靶标：DNA topoisomerase 1 External Id：CHEMBL4841208

实验名称：Binding affinity to DNA (unknown origin) assessed as change in melting temperature at... 来源：ChEMBL 靶标：DNA External Id：CHEMBL4841207

实验名称：Binding affinity to DNA (unknown origin) assessed as increase in fluorescence emissio... 来源：ChEMBL 靶标：DNA External Id：CHEMBL4841206

实验名称：Binding affinity to DNA in human NCI-H526 cells assessed as induction of cross-linkin... 来源：ChEMBL 靶标：DNA External Id：CHEMBL4841205

实验名称：Cytotoxicity against human CEM-VLB cells assessed as reduction in cell viability incu... 来源：ChEMBL 靶标：CEM-VLB External Id：CHEMBL4841188

实验名称：Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability inc... 来源：ChEMBL 靶标：CCRF-CEM External Id：CHEMBL4841187

实验名称：Antitumor activity against human 786-0 cells xenografted in athymic nu/nu mouse asses... 来源：ChEMBL 靶标：786-0 External Id：CHEMBL4841243

实验名称：Toxicity in athymic nu/nu mouse xenografted with human NCI-H526 cells assessed as cha... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4841242

实验名称：Antitumor activity against human NCI-H526 cells xenografted in athymic nu/nu mouse as... 来源：ChEMBL 靶标：NCI-H526 External Id：CHEMBL4841241

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