5-HT7R antagonist 1 free base

• 常用名: 5-HT7R antagonist 1 free base
• 英文名: 5-HT7R antagonist 1 free base
• CAS号: 2337008-64-5
• 分子量: 276.76
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₇ClN₄
• 熔点: N/A
• 闪点: N/A

5-HT7R antagonist 1 free base用途

5-HT7R拮抗剂1(游离碱基)是针对5-HT7R(Ki=6.5 nM)的G蛋白偏向性拮抗剂。

5-HT7R antagonist 1 free base名称

• 英文名: 5-HT7R antagonist 1 free base

5-HT7R antagonist 1 free base生物活性

• 描述: 5-HT7R拮抗剂1(游离碱基)是针对5-HT7R(Ki=6.5 nM)的G蛋白偏向性拮抗剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> GPCR19
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Kwag R, et al. Discovery of G Protein-Biased Antagonists against 5-HT7R. J Med Chem. 2021 Sep 23;64(18):13766-13779.

5-HT7R antagonist 1 free base物理化学性质

• 分子式: C₁₄H₁₇ClN₄
• 分子量: 276.76

5-HT7R antagonist 1 free base靶点实验

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实验名称：Effect on wild type mouse assessed as reduction in number of self grooming at 5 mg/kg... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828382

实验名称：Effect on shank3-/- mouse model of autism spectrum disorder assessed as reduction in ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4828383

实验名称：Inhibition of CYP1A2 in human liver microsomes assessed as remaining activity at 1 to... 来源：ChEMBL 靶标：Cytochrome P450 1A2 External Id：CHEMBL4828376

实验名称：Inhibition of CYP2C9 in human liver microsomes assessed as remaining activity at 1 to... 来源：ChEMBL 靶标：Cytochrome P450 2C9 External Id：CHEMBL4828377

实验名称：Selectivity index, ratio of Ki for 5HT5A receptor (unknown origin) to Ki for 5HT7 rec... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828374

实验名称：Selectivity index, ratio of Ki for 5HT6 receptor (unknown origin) to Ki for 5HT7 rece... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828375

实验名称：Effect on wild type mouse assessed as reduction in duration of self grooming at 5 mg/... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4828380

实验名称：Effect on shank3-/- mouse model of autism spectrum disorder assessed as reduction in ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4828381

实验名称：Inhibition of CYP2C19 in human liver microsomes assessed as remaining activity at 1 t... 来源：ChEMBL 靶标：Cytochrome P450 2C19 External Id：CHEMBL4828378

实验名称：Metabolic stability in human liver microsomes assessed as parent compound remaining a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828379

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