Antiviral agent 24

• 常用名: Antiviral agent 24
• 英文名: Antiviral agent 24
• CAS号: 23661-03-2
• 分子量: 425.36
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₈F₃N₅O₄
• 熔点: N/A
• 闪点: N/A

Antiviral agent 24用途

抗病毒药物24是一种有效的抗病毒药物,EV71、CVA21和EV68的EC50值分别为0.101、19.9和91.2µM。抗病毒药物24以剂量依赖的方式抑制METTL3/METTL14活性[1]。

Antiviral agent 24名称

• 英文名: Antiviral agent 24

Antiviral agent 24生物活性

• 描述: 抗病毒药物24是一种有效的抗病毒药物,EV71、CVA21和EV68的EC50值分别为0.101、19.9和91.2µM。抗病毒药物24以剂量依赖的方式抑制METTL3/METTL14活性[1]。
• 相关类别:
  研究领域 >> 感染
• 体外研究: 抗病毒剂24(化合物25)(0-1000µM)抑制 METTL3/METTL14标准复合物活性,第50周值为 129µM[1]
• 参考文献:

  [1]. Salerno M, et al. Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71. Eur J Med Chem. 2022 Nov 24;246:114942.

Antiviral agent 24物理化学性质

• 分子式: C₁₈H₁₈F₃N₅O₄
• 分子量: 425.36
• InChIKey: SDQKDCSBWUSBDO-LSCFUAHRSA-N
• SMILES: OCC1OC(n2cnc3c(NCc4cccc(C(F)(F)F)c4)ncnc32)C(O)C1O

Antiviral agent 24靶点实验

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实验名称：Antiviral activity against human Enterovirus 71 BrCr infected in human RD cells asses... 来源：ChEMBL 靶标：Enterovirus A71 External Id：CHEMBL5347334

实验名称：Cytotoxicity against African green monkey Vero cells assessed as reduction in cell vi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5523862

实验名称：Cytotoxicity against porcine PEK cells assessed as reduction in cell viability after ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5523861

实验名称：Cytokinin activity in Amaranthus cotyledons assessed as dark induction of betacyanin ... 来源：ChEMBL 靶标：Amaranthus External Id：CHEMBL905598

实验名称：Antiviral activity against WNV infected in African green monkey Vero cells assessed a... 来源：ChEMBL 靶标：West Nile virus External Id：CHEMBL5523860

实验名称：Antiviral activity against YFV infected in African green monkey Vero cells assessed a... 来源：ChEMBL 靶标：Yellow fever virus External Id：CHEMBL5523859

实验名称：Antiviral activity against TBEV infected in porcine PEK cells assessed as reduction i... 来源：ChEMBL 靶标：Tick-borne encephalitis virus External Id：CHEMBL5523858

实验名称：Cytokinin activity in tobacco assessed as stimulation of callus growth at at 1 umol/L... 来源：ChEMBL 靶标：Nicotiana tabacum External Id：CHEMBL905604

实验名称：Cytokinin activity in wheat assessed as retention of chlorophyll in excised wheat lea... 来源：ChEMBL 靶标：Triticum aestivum External Id：CHEMBL905600

实验名称：Antitumor activity against human HL60 cells after 72 hrs by Calcein AM assay 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL905611

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