ChemR23-IN-1

• 常用名: ChemR23-IN-1
• 英文名: ChemR23-IN-1
• CAS号: 2378640-10-7
• 分子量: 495.58
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₂₉N₇O₂
• 熔点: N/A
• 闪点: N/A

ChemR23-IN-1用途

ChemR23-IN-1(化合物2)是一种ChemR23抑制剂,对人和小鼠ChemR23的IC50s分别为38 nM和100 nM。ChemR23-IN-1在体外抑制由Chemerin触发的CAL-1趋化性[1]。

ChemR23-IN-1名称

• 英文名: ChemR23-IN-1

ChemR23-IN-1生物活性

• 描述: ChemR23-IN-1(化合物2)是一种ChemR23抑制剂,对人和小鼠ChemR23的IC50s分别为38 nM和100 nM。ChemR23-IN-1在体外抑制由Chemerin触发的CAL-1趋化性[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 靶点实验:

  IC50: 38 nM (human ChemR23 ) and 100 nM (mouse ChemR23)[1]

• 参考文献:

  [1]. Takamichi Imaizumi, et al. The design, synthesis and evaluation of 2-aminobenzoxazole analogues as potent and orally efficacious ChemR23 inhibitors. Bioorg Med Chem. 2020 Sep 1;28(17):115622.

ChemR23-IN-1物理化学性质

• 分子式: C₂₈H₂₉N₇O₂
• 分子量: 495.58

ChemR23-IN-1靶点实验

查看更多实验

实验名称：Inhibition of chemR23 expressed in mouse BA/F3 cells assessed as reduction in chemeri... 来源：ChEMBL 靶标：Chemerin-like receptor 1 External Id：CHEMBL4368344

实验名称：Agonist activity at chemR23 expressed in human CAL1 cells assessed as increase in int... 来源：ChEMBL 靶标：Chemerin-like receptor 1 External Id：CHEMBL4368343

实验名称：Inhibition of CXCR4 expressed in human CAL1 cells assessed as reduction in SDF1alpha-... 来源：ChEMBL 靶标：C-X-C chemokine receptor type 4 External Id：CHEMBL4368342

实验名称：Inhibition of chemR23 in human CAL1 cells assessed as reduction in chemerin-induced i... 来源：ChEMBL 靶标：Chemerin-like receptor 1 External Id：CHEMBL4368341

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