CBP/p300-IN-15

• 常用名: CBP/p300-IN-15
• 英文名: CBP/p300-IN-15
• CAS号: 2379409-91-1
• 分子量: 476.52
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₈N₄O₅
• 熔点: N/A
• 闪点: N/A

CBP/p300-IN-15用途

CBP/p300-IN-15(化合物13a)是一种有效的p300/CBP抑制剂,IC50值分别为2.50和28.0 nM。CBP/p300-IN-15对OVCAR-3和A2780细胞株表现出良好的活性,EC50值分别为0.865和2.71μM。CBP/p300-IN-15可用于卵巢癌研究[1]。

CBP/p300-IN-15名称

• 英文名: CBP/p300-IN-15

CBP/p300-IN-15生物活性

• 描述: CBP/p300-IN-15(化合物13a)是一种有效的p300/CBP抑制剂,IC50值分别为2.50和28.0 nM。CBP/p300-IN-15对OVCAR-3和A2780细胞株表现出良好的活性,EC50值分别为0.865和2.71μM。CBP/p300-IN-15可用于卵巢癌研究[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> 组蛋白乙酰转移酶
  信号通路 >> 表观遗传学 >> 表观遗传读者域
• 靶点实验:

  CBP:28.0 nM (IC50)

  p300:2.50 nM (IC50)

• 参考文献:

  [1]. Ding H, et al. Design, synthesis and biological evaluation of a novel spiro oxazolidinedione as potent p300/CBP HAT inhibitor for the treatment of ovarian cancer. Bioorg Med Chem. 2021 Dec 15;52:116512.

CBP/p300-IN-15物理化学性质

• 分子式: C₂₆H₂₈N₄O₅
• 分子量: 476.52

CBP/p300-IN-15靶点实验

查看更多实验

实验名称：Antiproliferative activity against human A2780 cells assessed as inhibition of cell p... 来源：ChEMBL 靶标：A2780 External Id：CHEMBL5033902

实验名称：Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell... 来源：ChEMBL 靶标：OVCAR-3 External Id：CHEMBL5033901

实验名称：Inhibition of CBP (unknown origin) preincubated for 15 mins followed by addition of s... 来源：ChEMBL 靶标：CREB-binding protein External Id：CHEMBL5033900

实验名称：Inhibition of p300 (unknown origin) preincubated for 15 mins followed by addition of ... 来源：ChEMBL 靶标：Histone acetyltransferase p300 External Id：CHEMBL5033899

实验名称：Stability in mouse liver microsomes assessed as intrinsic clearance 来源：ChEMBL 靶标：N/A External Id：CHEMBL5033905

实验名称：Stability in rat liver microsomes assessed as intrinsic clearance 来源：ChEMBL 靶标：N/A External Id：CHEMBL5033904

实验名称：Intrinsic clearance in mouse liver microsomes assessed per mg protein at 0.1 uM prein... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4325431

实验名称：Stability in human liver microsomes assessed as intrinsic clearance 来源：ChEMBL 靶标：N/A External Id：CHEMBL5033903

实验名称：Intrinsic clearance in rat liver microsomes assessed per mg protein at 0.1 uM preincu... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4325430

实验名称：Intrinsic clearance in human liver microsomes assessed per mg protein at 0.1 uM prein... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4325429

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