CDK4/6-IN-6

• 常用名: CDK4/6-IN-6
• 英文名: CDK4/6-IN-6
• CAS号: 2380321-51-5
• 分子量: 463.93
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₇ClFN₅O₃
• 熔点: N/A
• 闪点: N/A

CDK4/6-IN-6用途

CDK4/6-IN-6(示例A94)是一种有效的CDK4/CDK6抑制剂,对于CDK4/细胞周期蛋白D1和CDK6/细胞周期蛋白D3,Ki分别为0.6 nM和13.9 nM[1]。

CDK4/6-IN-6名称

• 英文名: CDK4/6-IN-6

CDK4/6-IN-6生物活性

• 描述: CDK4/6-IN-6(示例A94)是一种有效的CDK4/CDK6抑制剂,对于CDK4/细胞周期蛋白D1和CDK6/细胞周期蛋白D3,Ki分别为0.6 nM和13.9 nM[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> CDK
• 靶点实验:

  Cdk4/cyclin D1:0.6 nM (Ki)

  cdk6/cyclin D3:13.9 nM (Ki)

• 体外研究: 在JEKO-1和MV4-1细胞中使用磷酸化Rb S795 ELISA分析,CDK4/6-IN-6(实例A94)对CDK4/Cyclin D1和CDK6/Cyclin D3具有38.5 nM和144.9 nM的IC50[1]。
• 参考文献:

  [1]. Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.

CDK4/6-IN-6物理化学性质

• 分子式: C₂₂H₂₇ClFN₅O₃
• 分子量: 463.93
• InChIKey: QYJLBHRAPDJOSO-NVXWUHKLSA-N
• SMILES: CC(C)n1c(C(C)(C)O)nc2c(F)cc(-c3nc(NC4CCOCC4O)ncc3Cl)cc21

CDK4/6-IN-6靶点实验

查看更多实验

实验名称：Growth inhibition of human LNCaP/AR cells assessed as decrease in tumor spheroid grow... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5149898

实验名称：Biological Assay from US Patent US10766884: "Cyclin dependent kinase inhibitors" 来源：BindingDB 靶标：N/A External Id：BindingDB_9378_2

实验名称：Biological Assay from US Patent US10766884: "Cyclin dependent kinase inhibitors" 来源：BindingDB 靶标：N/A External Id：BindingDB_9378_1

实验名称：Growth inhibition of human LNCaP/AR cells assessed as decrease in tumor spheroid grow... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5149901

实验名称：Growth inhibition of human LNCaP/AR cells assessed as decrease in tumor spheroid grow... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5149895

实验名称：Mobility Shift Assay from US Patent US11220494: "Cyclin dependent kinase inhibitors" 来源：BindingDB 靶标：N/A External Id：BindingDB_10401_2

实验名称：Growth inhibition of human LNCaP/AR cells assessed as decrease in tumor spheroid grow... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5149896

实验名称：Mobility Shift Assay from US Patent US11220494: "Cyclin dependent kinase inhibitors" 来源：BindingDB 靶标：N/A External Id：BindingDB_10401_1

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