Anhydroerythromycin A

• 常用名: Anhydroerythromycin A
• 英文名: Anhydroerythromycin A
• CAS号: 23893-13-2
• 分子量: 715.911
• 密度: 1.2±0.1 g/cm3
• 沸点: 787.2±60.0 °C at 760 mmHg
• 分子式: C₃₇H₆₅NO₁₂
• 熔点: 125-127ºC
• 闪点: 429.9±32.9 °C

Anhydroerythromycin A用途

脱水红霉素A是大环内酯类抗生素红霉素的降解产物。酸酐红霉素A是红霉素在酸性水溶液中降解而成的。脱水红霉素A在体外对金黄色葡萄球菌和蜡样芽胞杆菌具有活性(MIC分别为12.5和6.25μg/ml)。脱水红霉素A还抑制人肝微粒体中与细胞色素P450(CYP)异构体CYP3A相关的甾体6β-羟化酶活性。

Anhydroerythromycin A名称

• 英文名: Anhydro Erythromycin A

Anhydroerythromycin A生物活性

• 描述: 脱水红霉素A是大环内酯类抗生素红霉素的降解产物。酸酐红霉素A是红霉素在酸性水溶液中降解而成的。脱水红霉素A在体外对金黄色葡萄球菌和蜡样芽胞杆菌具有活性(MIC分别为12.5和6.25μg/ml)。脱水红霉素A还抑制人肝微粒体中与细胞色素P450(CYP)异构体CYP3A相关的甾体6β-羟化酶活性。

Anhydroerythromycin A物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 787.2±60.0 °C at 760 mmHg
• 熔点: 125-127ºC
• 分子式: C₃₇H₆₅NO₁₂
• 分子量: 715.911
• 闪点: 429.9±32.9 °C
• 精确质量: 715.450684
• PSA: 154.84000
• LogP: 3.93
• 蒸汽压: 0.0±6.2 mmHg at 25°C
• 折射率: 1.540
• 储存条件: −20°C

Anhydroerythromycin A安全信息

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport

Anhydroerythromycin A英文别名

• Erythromycin Anhydride,Impurity D
• (1S,2R,3R,4S,5R,8R,9S,10S,11R,12R,14R)-11-{[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-5-ethyl-3-hydroxy-9-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahyd ;ro-2H-pyran-2-yl]oxy}-2,4,8,10,12,14-hexamethyl-6,15,16-trioxatricyclo[10.2.1.1]hexadecan-7-one (non-preferred name)
• Erythromycin,9-deoxo-6,12-dideoxy-6,9:9,12-diepoxy
• ANHYDROERYTHROMYCIN A
• EM 202
• 9-Deoxo-6,12-dideoxy-6,9:9,12-diepoxy-erythromycin
• Erythromycin anhydride
• Anhydroerythromycin
• (1S,2R,3R,4S,5R,8R,9S,10S,11R,12R,14R)-11-{[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-5-ethyl-3-hydroxy-9-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahyd ;ro-2H-pyran-2-yl]oxy}-2,4,8,10,12,14-hexamethyl-6,15,16-trioxatricyclo[10.2.1.1]hexadecan-7-one
• 6,9,12-Anhydroerythromycin A
• 6,9:9,12-Diepoxy-9-deoxo-6,12-dideoxyerythromycin