23893-13-2

• 常用中文名：Anhydroerythromycin A
• 常用英文名：Anhydroerythromycin A
• CAS号：23893-13-2
• 分子式：C₃₇H₆₅NO₁₂
• 分子量：715.911
• 相关类别： 分析化学 分析试剂 离子色谱试剂
• 发布时间：2017-04-29 17:50:25
• 更新时间：2024-01-03 21:11:38
• 脱水红霉素A是大环内酯类抗生素红霉素的降解产物。酸酐红霉素A是红霉素在酸性水溶液中降解而成的。脱水红霉素A在体外对金黄色葡萄球菌和蜡样芽胞杆菌具有活性(MIC分别为12.5和6.25μg/ml)。脱水红霉素A还抑制人肝微粒体中与细胞色素P450(CYP)异构体CYP3A相关的甾体6β-羟化酶活性。

名称

• 英文名: Anhydro Erythromycin A
• 英文别名: Erythromycin Anhydride,Impurity D; (1S,2R,3R,4S,5R,8R,9S,10S,11R,12R,14R)-11-{[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-5-ethyl-3-hydroxy-9-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahyd ;ro-2H-pyran-2-yl]oxy}-2,4,8,10,12,14-hexamethyl-6,15,16-trioxatricyclo[10.2.1.1]hexadecan-7-one (non-preferred name); Erythromycin,9-deoxo-6,12-dideoxy-6,9:9,12-diepoxy; ANHYDROERYTHROMYCIN A; EM 202; 9-Deoxo-6,12-dideoxy-6,9:9,12-diepoxy-erythromycin; Erythromycin anhydride; Anhydroerythromycin; (1S,2R,3R,4S,5R,8R,9S,10S,11R,12R,14R)-11-{[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-5-ethyl-3-hydroxy-9-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahyd ;ro-2H-pyran-2-yl]oxy}-2,4,8,10,12,14-hexamethyl-6,15,16-trioxatricyclo[10.2.1.1]hexadecan-7-one; 6,9,12-Anhydroerythromycin A; 6,9:9,12-Diepoxy-9-deoxo-6,12-dideoxyerythromycin

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 787.2±60.0 °C at 760 mmHg
• 熔点: 125-127ºC
• 分子式: C₃₇H₆₅NO₁₂
• 分子量: 715.911
• 闪点: 429.9±32.9 °C
• 精确质量: 715.450684
• PSA: 154.84000
• LogP: 3.93
• 蒸汽压: 0.0±6.2 mmHg at 25°C
• 折射率: 1.540
• 储存条件: −20°C

生物活性

• 描述: 脱水红霉素A是大环内酯类抗生素红霉素的降解产物。酸酐红霉素A是红霉素在酸性水溶液中降解而成的。脱水红霉素A在体外对金黄色葡萄球菌和蜡样芽胞杆菌具有活性(MIC分别为12.5和6.25μg/ml)。脱水红霉素A还抑制人肝微粒体中与细胞色素P450(CYP)异构体CYP3A相关的甾体6β-羟化酶活性。

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport

合成路线

114-07-8 ~% 23893-13-2

文献：Journal of Organic Chemistry, , vol. 52, # 6 p. 990 - 996

33396-29-1 ~% 23893-13-2

文献：Kibwage, Isaac O.; Busson, Roger; Janssen, Gerard; Hoogmartens, Jos; Vanderhaeghe, Hubert Journal of Organic Chemistry, 1987 , vol. 52, # 6 p. 990 - 996

105900-46-7 ~% 23893-13-2

文献：Journal of Organic Chemistry, , vol. 52, # 6 p. 990 - 996

105882-69-7 ~% 23893-13-2

文献：Journal of Organic Chemistry, , vol. 52, # 6 p. 990 - 996

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