Steroid sulfatase-IN-1

• 常用名: Steroid sulfatase-IN-1
• 英文名: Steroid sulfatase-IN-1
• CAS号: 2403716-19-6
• 分子量: 385.23
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₀Cl₂N₄O₃S
• 熔点: N/A
• 闪点: N/A

Steroid sulfatase-IN-1用途

类固醇硫酸酯酶-IN-1是一种有效的口服活性类固醇硫酸酯酶抑制剂,IC50为1.71µM。类固醇硫酸酯酶-IN-1在体内具有抗肿瘤活性(TGI=51%)。类固醇硫酸酯酶-IN-1在乳腺癌研究中具有潜在的应用价值[1]。

Steroid sulfatase-IN-1名称

• 英文名: Steroid sulfatase-IN-1

Steroid sulfatase-IN-1生物活性

• 描述: 类固醇硫酸酯酶-IN-1是一种有效的口服活性类固醇硫酸酯酶抑制剂,IC50为1.71µM。类固醇硫酸酯酶-IN-1在体内具有抗肿瘤活性(TGI=51%)。类固醇硫酸酯酶-IN-1在乳腺癌研究中具有潜在的应用价值[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 靶点实验:

  IC50: 1.71 µM (Steroid sulfatase)[1]

• 体内研究: 甾体硫酸酯酶-IN-1(化合物4 b)(50 mg/kg；p.o.)显示出显著的抗肿瘤活性,TGI值为51%[1]。动物模型：67NR小鼠【1】剂量：50 mg/kg给药：P.o。结果：显示出显著的抗肿瘤活性,TGI值为51%。
• 参考文献:

  [1]. Biernacki K, et al. Development of Sulfamoylated 4-(1-Phenyl-1H-1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer. J Med Chem. 2022; 65(6):5044-5056.

Steroid sulfatase-IN-1物理化学性质

• 分子式: C₁₄H₁₀Cl₂N₄O₃S
• 分子量: 385.23
• InChIKey: LVZFTBZGLNBDFP-UHFFFAOYSA-N
• SMILES: NS(=O)(=O)Oc1ccc(-c2cn(-c3cc(Cl)cc(Cl)c3)nn2)cc1

Steroid sulfatase-IN-1靶点实验

查看更多实验

实验名称：Toxicity in BALB/c mouse allografted with mouse 67NR cells assessed as increase in bl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5160477

实验名称：Inhibition of STS in human MCF7 cells assessed as residual enzyme activity using [3H]... 来源：ChEMBL 靶标：Steryl-sulfatase External Id：CHEMBL5160479

实验名称：Inhibition of STS in human MCF7 cells assessed as residual enzyme activity using [3H]... 来源：ChEMBL 靶标：Steryl-sulfatase External Id：CHEMBL5160478

实验名称：Toxicity in BALB/c mouse allografted with mouse 67NR cells assessed as increase in gr... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5160473

实验名称：Toxicity in BALB/c mouse allografted with mouse 67NR cells assessed as increase in mo... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5160472

实验名称：Toxicity in BALB/c mouse allografted with mouse 67NR cells assessed as effect on hema... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5160475

实验名称：Toxicity in BALB/c mouse allografted with mouse 67NR cells assessed as effect on hemo... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5160474

实验名称：Toxicity in BALB/c mouse allografted with mouse 67NR cells assessed as decrease in ly... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5160471

实验名称：Toxicity in BALB/c mouse allografted with mouse 67NR cells assessed as decrease in sp... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5160470

实验名称：Antitumor activity against mouse 67NR cells allografted in BALB/c mouse assessed as t... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5160465

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