TRβ agonist 3

更新时间：2025-08-26 19:10:10

TRβ agonist 3用途

TRβ激动剂3(化合物3)是一种有效的TRβ激动剂。TRβ激动剂3可减少HepG2中的脂质积聚,并促进脂解,具有类似的效果。TRβ激动剂3是一种潜在的TRβ选择性拟甲状腺药物。

英文名	TRβ agonist 3

描述	TRβ激动剂3(化合物3)是一种有效的TRβ激动剂。TRβ激动剂3可减少HepG2中的脂质积聚,并促进脂解,具有类似的效果。TRβ激动剂3是一种潜在的TRβ选择性拟甲状腺药物。
相关类别	信号通路 >> 其他 >> 甲状腺激素受体研究领域 >> 代谢疾病
参考文献	[1]. Runfola M, et al. Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis. Eur J Med Chem. 2020 Feb 15;188:112006.

分子式	C₂₀H₂₅NO₃
分子量	327.42

实验名称：Cytotoxicity against human U2OS cells assessed as cell growth inhibition at 10 uM aft...
来源：ChEMBL
靶标：U2OS
External Id：CHEMBL4683739

实验名称：Cytotoxicity against human HEK293 cells assessed as cell growth inhibition at 10 uM a...
来源：ChEMBL
靶标：HEK293
External Id：CHEMBL4683741

实验名称：Cytotoxicity against human U2OS cells assessed as cell growth inhibition at 10 uM aft...
来源：ChEMBL
靶标：U2OS
External Id：CHEMBL4683740

实验名称：Cytotoxicity against human hTERT cells assessed as cell growth inhibition at 10 uM af...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4683743

实验名称：Cytotoxicity against human HEK293 cells assessed as cell growth inhibition at 10 uM a...
来源：ChEMBL
靶标：HEK293
External Id：CHEMBL4683742

实验名称：Cytotoxicity against human MCF7 cells assessed as cell growth inhibition at 10 uM aft...
来源：ChEMBL
靶标：MCF7
External Id：CHEMBL4683745

实验名称：Cytotoxicity against human hTERT cells assessed as cell growth inhibition at 10 uM af...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4683744

实验名称：Toxicity in F344 rat assessed as effect on serum AST/GOT level at 100 ug per 100 g bo...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4683771

实验名称：Toxicity in F344 rat assessed as effect on serum AST/GOT level at 75 ug per 100 g of ...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4683770

实验名称：Toxicity in F344 rat assessed as effect on serum ALT/GPT level at 50 ug per 100 g bod...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4683773

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