CD73-IN-5

• 常用名: CD73-IN-5
• 英文名: CD73-IN-5
• CAS号: 2412019-99-7
• 分子量: 434.43
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₁₅FN₈
• 熔点: N/A
• 闪点: N/A

CD73-IN-5用途

CD73-IN-5是一种有效的、选择性的非核苷酸小分子CD73抑制剂(IC50=19nm)。

CD73-IN-5名称

• 英文名: CD73-IN-5

CD73-IN-5生物活性

• 描述: CD73-IN-5是一种有效的、选择性的非核苷酸小分子CD73抑制剂(IC50=19nm)。
• 相关类别:
  研究领域 >> 癌症
• 参考文献:

  [1]. Beatty JW, et al. Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73. J Med Chem. 2020 Apr 23;63(8):3935-3955.

CD73-IN-5物理化学性质

• 分子式: C₂₄H₁₅FN₈
• 分子量: 434.43
• InChIKey: SWFRQIKTNNVFAU-UHFFFAOYSA-N
• SMILES: N#Cc1ccc(Cn2nccc2-c2cc(F)c3nnn(-c4ccc5cn[nH]c5c4)c3c2)cc1

CD73-IN-5靶点实验

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实验名称：Metabolic stability in human Hepatocyte assessed as intrinsic clearance at 0.5 uM mea... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4405661

实验名称：Metabolic stability in human Hepatocyte assessed as half life at 0.5 uM by LC-MS/MS a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4405662

实验名称：Inhibition of human liver microsome CYP1A2 using phenacetin as substrate incubated fo... 来源：ChEMBL 靶标：Cytochrome P450 1A2 External Id：CHEMBL4405663

实验名称：Inhibition of CD73 (unknown origin) 来源：ChEMBL 靶标：5'-nucleotidase External Id：CHEMBL5511376

实验名称：Inhibition of human liver microsome CYP2C9 using diclofenac as substrate incubated fo... 来源：ChEMBL 靶标：Cytochrome P450 2C9 External Id：CHEMBL4405664

实验名称：Inhibition of human liver microsome CYP2C19 using S-mephenytoin as substrate incubate... 来源：ChEMBL 靶标：Cytochrome P450 2C19 External Id：CHEMBL4405665

实验名称：Inhibition of human liver microsome CYP2D6 using dextromethorphan as substrate incuba... 来源：ChEMBL 靶标：Cytochrome P450 2D6 External Id：CHEMBL4405666

实验名称：Inhibition of human liver microsome CYP3A4 using midazolam as substrate incubated for... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL4405667

实验名称：Inhibition of recombinant human CD73 expressed in CHO cells using AMP as substrate pr... 来源：ChEMBL 靶标：5'-nucleotidase External Id：CHEMBL4405659

实验名称：Inhibition of recombinant human CD73 expressed in CHO cells in 2 % DMSO using AMP as ... 来源：ChEMBL 靶标：5'-nucleotidase External Id：CHEMBL4405660

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