Chk1-IN-6

• 常用名: Chk1-IN-6
• 英文名: Chk1-IN-6
• CAS号: 2428423-77-0
• 分子量: 365.36
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₈F₃N₇
• 熔点: N/A
• 闪点: N/A

Chk1-IN-6用途

Chk1-IN-6是一种强效、选择性和口服生物利用的Chk1抑制剂候选药物。

Chk1-IN-6名称

• 英文名: Chk1-IN-6

Chk1-IN-6生物活性

• 描述: Chk1-IN-6是一种强效、选择性和口服生物利用的Chk1抑制剂候选药物。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 检查点激酶(Chk)
• 靶点实验:

  Chk1

• 参考文献:

  [1]. Jin T, et al. Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile. J Med Chem. 2021 Oct 28;64(20):15069-15090.

Chk1-IN-6物理化学性质

• 分子式: C₁₆H₁₈F₃N₇
• 分子量: 365.36

Chk1-IN-6靶点实验

查看更多实验

实验名称：Antiproliferative activity against human RPMI-8226 cells incubated for 72 hrs in pres... 来源：ChEMBL 靶标：RPMI-8226 External Id：CHEMBL4831418

实验名称：Antiproliferative activity against human A549 cells incubated for 72 hrs in presence ... 来源：ChEMBL 靶标：A549 External Id：CHEMBL4831417

实验名称：Antiproliferative activity against human HT-29 cells incubated for 72 hrs in presence... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL4831416

实验名称：Antiproliferative activity against human RPMI-8226 cells incubated for 72 hrs by CCK8... 来源：ChEMBL 靶标：RPMI-8226 External Id：CHEMBL4831415

实验名称：Inhibition of CHK1 in human MV4-11 cells assessed as increase in phosphorylation at S... 来源：ChEMBL 靶标：Serine/threonine-protein kinase Chk1 External Id：CHEMBL4831422

实验名称：Inhibition of CHK1 in human MV4-11 cells assessed as reduction in autophosphorylation... 来源：ChEMBL 靶标：Serine/threonine-protein kinase Chk1 External Id：CHEMBL4831421

实验名称：Selectivity ratio of Antiproliferative activity against human RPMI-8226 cells to Anti... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4831420

实验名称：Selectivity ratio of Antiproliferative activity against human A549 cells to Antiproli... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4831419

实验名称：Inhibition of wild type human RSK3 expressed in bacterial expression system assessed ... 来源：ChEMBL 靶标：Ribosomal protein S6 kinase alpha-2 External Id：CHEMBL4831410

实验名称：Inhibition of wild type human RSK2 expressed in mammalian expression system assessed ... 来源：ChEMBL 靶标：Ribosomal protein S6 kinase alpha-3 External Id：CHEMBL4831409

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