MAT2A inhibitor 3

• 常用名: MAT2A inhibitor 3
• 英文名: MAT2A inhibitor 3
• CAS号: 2439271-82-4
• 分子量: 299.75
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₄ClN₃O
• 熔点: N/A
• 闪点: N/A

MAT2A inhibitor 3用途

MAT2A抑制剂3是从专利WO2020123395A1化合物24中提取的甲硫氨酸腺苷转移酶2A(MAT2A)抑制剂,其IC50小于200 nM。MAT2A抑制剂3可用于癌症研究[1]。

MAT2A inhibitor 3名称

• 英文名: MAT2A inhibitor 3

MAT2A inhibitor 3生物活性

• 描述: MAT2A抑制剂3是从专利WO2020123395A1化合物24中提取的甲硫氨酸腺苷转移酶2A(MAT2A)抑制剂,其IC50小于200 nM。MAT2A抑制剂3可用于癌症研究[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 靶点实验:

  IC50: <200 nM (MAT2A)[1]

• 体外研究: MAT2A抑制剂3是一种有效的蛋氨酸腺苷转移酶2A抑制剂,IC50小于200 nM[1]。
• 参考文献:

  [1]. Alam M, et, al. 2-oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors. WO2020123395A1.

MAT2A inhibitor 3物理化学性质

• 分子式: C₁₆H₁₄ClN₃O
• 分子量: 299.75

MAT2A inhibitor 3靶点实验

查看更多实验

实验名称：Selectivity index, ratio of IC50 for antiproliferative activity against wild type hum... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5512205

实验名称：Biochemical Assay from US Patent US11084798: "2-oxoquinazoline derivatives as methion... 来源：BindingDB 靶标：N/A External Id：BindingDB_10070_1

实验名称：Antiproliferative activity against wild type human HCT116 cells assessed as cell viab... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5512204

实验名称：Antiproliferative activity against MTAP-knock out human HCT-116 cells assessed as cel... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5512203

实验名称：Inhibition of MAT2A in MTAP-knock out human HCT-116 cells assessed as reduction in PR... 来源：ChEMBL 靶标：S-adenosylmethionine synthase isoform type-2 External Id：CHEMBL5512202

实验名称：Inhibition of MAT2A (unknown origin) assessed as release of inorganic phosphate using... 来源：ChEMBL 靶标：S-adenosylmethionine synthase isoform type-2 External Id：CHEMBL5512200

实验名称：Malachite Green Assay from US Patent US11046691: "2-oxoquinazoline derivatives as met... 来源：BindingDB 靶标：N/A External Id：BindingDB_10012_1

实验名称：Toxicity in NCR mouse xenografted with human HCT116-MTAP null cells assessed as body ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5036639

实验名称：Antitumor activity against human HCT116-MTAP null cells xenografted in NCR nude mouse... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5036638

实验名称：Oral bioavailability in mouse at 1 mg/kg 来源：ChEMBL 靶标：N/A External Id：CHEMBL5036637

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