AKT-IN-13

• 常用名: AKT-IN-13
• 英文名: AKT-IN-13
• CAS号: 2459489-51-9
• 分子量: 470.99
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₃₁ClN₆O₂
• 熔点: N/A
• 闪点: N/A

AKT-IN-13用途

AKT-IN-13(化合物4b)是一种有效的AKT抑制剂,其对Akt1、Akt2和Akt3的IC50s分别为1.6nm、2.4nm和0.3nm。AKT-IN-13可用于研究抗癌药物[1]。

AKT-IN-13名称

• 英文名: AKT-IN-13

AKT-IN-13生物活性

• 描述: AKT-IN-13(化合物4b)是一种有效的AKT抑制剂,其对Akt1、Akt2和Akt3的IC50s分别为1.6nm、2.4nm和0.3nm。AKT-IN-13可用于研究抗癌药物[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AKT
• 靶点实验:

  Akt1:1.6 nM (IC50)

  Akt2:2.4 nM (IC50)

  Akt3:0.3 nM (IC50)

• 体外研究: AKT-IN-13(化合物4b)在LNCap细胞系中表现出良好的效力,IC50值为103 nM,游离分数高,人血浆蛋白结合率(PPB)为51.3%[1]。
• 参考文献:

  [1]. Ma C, et al. Discovery of Clinical Candidate NTQ1062 as a Potent and Bioavailable Akt Inhibitor for the Treatment of Human Tumors. J Med Chem. 2022 Jun 23;65(12):8144-8168.

AKT-IN-13物理化学性质

• 分子式: C₂₄H₃₁ClN₆O₂
• 分子量: 470.99

AKT-IN-13靶点实验

查看更多实验

实验名称：MRT(0 to t) in overnight fasted ICR mouse at 10 mg/kg, po measured upto 24 hrs by UPL... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5168701

实验名称：AUC (0 to infinity) in overnight fasted ICR mouse at 10 mg/kg, po measured upto 24 hr... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5168700

实验名称：In vivo antitumor activity against human LNCap cells xenografted in NCG mouse assesse... 来源：ChEMBL 靶标：LNCaP External Id：CHEMBL5168703

实验名称：Oral bioavailability in overnight fasted ICR mouse at 10 mg/kg measured upto 24 hrs b... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5168702

实验名称：Half life in ICR mouse at 2 mg/kg, iv measured upto 24 hrs by UPLC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5168697

实验名称：AUC (0 to infinity) in ICR mouse at 2 mg/kg, iv measured upto 24 hrs by UPLC-MS/MS an... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5168696

实验名称：Tmax in overnight fasted ICR mouse at 10 mg/kg, po measured upto 24 hrs by UPLC-MS/MS... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5168699

实验名称：Clearance in ICR mouse at 2 mg/kg, iv measured upto 24 hrs by UPLC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5168695

实验名称：Plasma protein binding in human at 1 to 100 uM incubated for 16 hrs by UPLC-MS/MS ana... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5168689

实验名称：Plasma protein binding in human assessed as unbound fraction at 1 to 100 uM incubated... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5168691

共11条，当前第1页，共2页

1

2