ChemR23-IN-2

• 常用名: ChemR23-IN-2
• 英文名: ChemR23-IN-2
• CAS号: 2465086-50-2
• 分子量: 510.54
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₂₆N₄O₅
• 熔点: N/A
• 闪点: N/A

ChemR23-IN-2用途

ChemR23-IN-2是一种有效的口服ChemR23抑制剂,IC50值为3.2 nM。

ChemR23-IN-2名称

• 英文名: ChemR23-IN-2

ChemR23-IN-2生物活性

• 描述: ChemR23-IN-2是一种有效的口服ChemR23抑制剂,IC50值为3.2 nM。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Imaizumi T, et al. The design, synthesis and evaluation of 2-aminobenzoxazole analogues as potent and orally efficacious ChemR23 inhibitors. Bioorg Med Chem. 2020 Sep 1;28(17):115622.

ChemR23-IN-2物理化学性质

• 分子式: C₂₉H₂₆N₄O₅
• 分子量: 510.54
• InChIKey: FWMIYMSIZWIVNI-QGZVFWFLSA-N
• SMILES: Cc1ccc(-c2noc(=O)[nH]2)c(-c2ccc(C(C)N(CC3CC3)c3nc4c(C(=O)O)cccc4o3)cc2)c1
• 储存条件: 2-8°C，密封，干燥

ChemR23-IN-2靶点实验

查看更多实验

实验名称：AUC (0 to infinity) in cynomolgus monkey at 1 mg/kg, po administered as cassette dose... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4727809

实验名称：Fraction unbound in cynomolgus monkey plasma at 1 mg/kg, po administered as cassette ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4727810

实验名称：Cmax in cynomolgus monkey at 1 mg/kg, po administered as cassette dose by LC-MS/MS an... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4727807

实验名称：Half-life in cynomolgus monkey at 1 mg/kg, po administered as cassette dose by LC-MS/... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4727808

实验名称：Half-life in cynomolgus monkey at 10 mg/kg, po by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4727813

实验名称：AUC (0 to infinity) in cynomolgus monkey at 10 mg/kg, po by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4727814

实验名称：Oral bioavailability in cynomolgus monkey at 1 mg/kg and 0.1 mg/kg, iv administered a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4727811

实验名称：Inhibition of chemR23 in human CAL1 cells assessed as inhibition of chemerin-induced ... 来源：ChEMBL 靶标：Chemerin-like receptor 1 External Id：CHEMBL4727805

实验名称：Ratio of fraction unbound in cynomolgus monkey plasma at 10 mg/kg to IC50 of inhibiti... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4727806

实验名称：Induction of chemR23 internalization on pDCs of cynomolgus monkey assessed as chemR23... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4727825

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