Trk-IN-6

• 常用名: Trk-IN-6
• 英文名: Trk-IN-6
• CAS号: 2489327-43-5
• 分子量: 446.43
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₁F₃N₆O₂
• 熔点: N/A
• 闪点: N/A

Trk-IN-6用途

Trk-IN-6在一组Trk突变体(IC50=0.2-0.7nm)上显示出优异的体外效力。

Trk-IN-6名称

• 英文名: Trk-IN-6

Trk-IN-6生物活性

• 描述: Trk-IN-6在一组Trk突变体(IC50=0.2-0.7nm)上显示出优异的体外效力。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> Trk Receptor
• 参考文献:

  [1]. Zhuo LS, et al. Discovery of Next-Generation Tropomyosin Receptor Kinase Inhibitors for Combating Multiple Resistance Associated with Protein Mutation. J Med Chem. 2021 Oct 28;64(20):15503-15514.

Trk-IN-6物理化学性质

• 分子式: C₂₁H₂₁F₃N₆O₂
• 分子量: 446.43
• InChIKey: GYWAMONQPZXXDB-CYBMUJFWSA-N
• SMILES: CC(Nc1ccn2ncc(-c3cnn(CCO)c3)c2n1)c1cc(F)ccc1OCC(F)F

Trk-IN-6靶点实验

查看更多实验

实验名称：Clearance in Beagle dog at 1 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5035690

实验名称：Volume of distribution in Beagle dog at 5 mg/kg, ig measured upto 24 hrs by LC-MS/MS ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5035689

实验名称：Volume of distribution in Beagle dog at 1 mg/kg, iv measured upto 24 hrs by LC-MS/MS ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5035688

实验名称：AUC(0 to infinity) in Beagle dog at 1 mg/kg, iv measured upto 24 hrs by LC-MS/MS anal... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5035687

实验名称：Plasma protein binding in human 来源：ChEMBL 靶标：N/A External Id：CHEMBL5035694

实验名称：Plasma protein binding in rat 来源：ChEMBL 靶标：N/A External Id：CHEMBL5035693

实验名称：Oral bioavailability in Beagle dog at 5 mg/kg measured upto 24 hrs by LC-MS/MS analys... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5035692

实验名称：Clearance in Beagle dog at 5 mg/kg, ig measured upto 24 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5035691

实验名称：Half life in Beagle dog at 1 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5035682

实验名称：AUC(0 to infinity) in Beagle dog at 5 mg/kg, ig measured upto 24 hrs by LC-MS/MS anal... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5035681

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