BRAF V600E/CRAF-IN-1

• 常用名: BRAF V600E/CRAF-IN-1
• 英文名: BRAF V600E/CRAF-IN-1
• CAS号: 2499499-56-6
• 分子量: 505.41
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₁₇F₆N₃O₂
• 熔点: N/A
• 闪点: N/A

BRAF V600E/CRAF-IN-1用途

BRAF V600E/CRAF-IN-1(化合物8b)是BRAF V600E/CRAF的有效抑制剂。BRAF V600E/CRAF-IN-1触发HCT-116结肠癌细胞G0/G1期凋亡和细胞周期阻滞。BRAF V600E/CRAF-IN-1具有研究癌症疾病的潜力【1】。

BRAF V600E/CRAF-IN-1名称

• 英文名: BRAF V600E/CRAF-IN-1

BRAF V600E/CRAF-IN-1生物活性

• 描述: BRAF V600E/CRAF-IN-1(化合物8b)是BRAF V600E/CRAF的有效抑制剂。BRAF V600E/CRAF-IN-1触发HCT-116结肠癌细胞G0/G1期凋亡和细胞周期阻滞。BRAF V600E/CRAF-IN-1具有研究癌症疾病的潜力【1】。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> MAPK/ERK信号通路 >> 拉夫
• 参考文献:

  [1]. El-Damasy AK, et al. 2-Anilinoquinoline based arylamides as broad spectrum anticancer agents with B-RAFV600E/C-RAF kinase inhibitory effects: Design, synthesis, in vitro cell-based and oncogenic kinase assessments. Eur J Med Chem. 2020 Dec 15;208:112756.

BRAF V600E/CRAF-IN-1物理化学性质

• 分子式: C₂₅H₁₇F₆N₃O₂
• 分子量: 505.41
• InChIKey: ZOFPYTOXNJKYQJ-UHFFFAOYSA-N
• SMILES: COc1cccc2nc(Nc3cccc(NC(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)c3)ccc12

BRAF V600E/CRAF-IN-1靶点实验

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实验名称：Growth inhibition of human Panel NCI-60 (60 carcinoma cell lines) cells at 10 uM meas... 来源：ChEMBL 靶标：Panel NCI-60 (60 carcinoma cell lines) External Id：CHEMBL4710851

实验名称：Growth inhibition of human 786-0 cells at 10 uM measured after 48 hrs by SRB assay re... 来源：ChEMBL 靶标：786-0 External Id：CHEMBL4710862

实验名称：Growth inhibition of human A498 cells at 10 uM measured after 48 hrs by SRB assay rel... 来源：ChEMBL 靶标：A498 External Id：CHEMBL4710863

实验名称：Growth inhibition of human HCT-116 cells at 10 uM measured after 48 hrs by SRB assay ... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4710860

实验名称：Growth inhibition of human HT-29 cells at 10 uM measured after 48 hrs by SRB assay re... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL4710861

实验名称：Growth inhibition of human T47D cells at 10 uM measured after 48 hrs by SRB assay rel... 来源：ChEMBL 靶标：T47D External Id：CHEMBL4710866

实验名称：Growth inhibition of human UO-31 cells at 10 uM measured after 48 hrs by SRB assay re... 来源：ChEMBL 靶标：UO-31 External Id：CHEMBL4710864

实验名称：Growth inhibition of human PC-3 cells at 10 uM measured after 48 hrs by SRB assay rel... 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL4710865

实验名称：Growth inhibition of human MOLT-4 cells at 10 uM measured after 48 hrs by SRB assay r... 来源：ChEMBL 靶标：MOLT-4 External Id：CHEMBL4710854

实验名称：Growth inhibition of human RPMI-8226 cells at 10 uM measured after 48 hrs by SRB assa... 来源：ChEMBL 靶标：RPMI-8226 External Id：CHEMBL4710855

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