TbPTR1 inhibitor 1

• 常用名: TbPTR1 inhibitor 1
• 英文名: TbPTR1 inhibitor 1
• CAS号: 2499713-65-2
• 分子量: 399.45
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₁N₇O
• 熔点: N/A
• 闪点: N/A

TbPTR1 inhibitor 1用途

TbPTR1抑制剂1(化合物5d)是一种有效的动质体蝶啶还原酶1(PTR1)抑制剂,对TbPTR1的IC50<0.1 nM。TbPTR1抑制物1对布氏锥虫具有抑制活性(EC50=0.66μM)[1]。

TbPTR1 inhibitor 1名称

• 英文名: TbPTR1 inhibitor 1

TbPTR1 inhibitor 1生物活性

• 描述: TbPTR1抑制剂1(化合物5d)是一种有效的动质体蝶啶还原酶1(PTR1)抑制剂,对TbPTR1的IC50<0.1 nM。TbPTR1抑制物1对布氏锥虫具有抑制活性(EC50=0.66μM)[1]。
• 相关类别:
  研究领域 >> 感染
• 靶点实验:

  IC50: <0.1 nM (TbPTR1)[1]

• 参考文献:

  [1]. Pöhner I, et al. Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. J Med Chem. 2022 Jun 8.

TbPTR1 inhibitor 1物理化学性质

• 分子式: C₂₂H₂₁N₇O
• 分子量: 399.45
• InChIKey: ASBJYAZYFSRQAB-UHFFFAOYSA-N
• SMILES: CCN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)c2ccccc2)cc1

TbPTR1 inhibitor 1靶点实验

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实验名称：Inhibition of recombinant Trypanosoma brucei PTR1 expressed in Escherichia coli BL21 ... 来源：ChEMBL 靶标：Pteridine reductase, putative External Id：CHEMBL5148453

实验名称：Inhibition of CYP2D6 (unknown origin) expressed in baculovirus-infected insect cells ... 来源：ChEMBL 靶标：Cytochrome P450 2D6 External Id：CHEMBL5148470

实验名称：Inhibition of CYP3A4 (unknown origin) expressed in baculovirus-infected insect cells ... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL5148471

实验名称：Mitochondrial toxicity in human 786-0 cells at 10 uM incubated with compound for 6 hr... 来源：ChEMBL 靶标：786-0 External Id：CHEMBL5148472

实验名称：Cytotoxicity against human A549 cells at 10 uM measured after 48 hrs by Celltiter-Glo... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5148473

实验名称：Inhibition of hERG potassium channel at 10 uM by fluorescence polarization assay rela... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL5148466

实验名称：Inhibition of CYP1A2 (unknown origin) expressed in baculovirus-infected insect cells ... 来源：ChEMBL 靶标：Cytochrome P450 1A2 External Id：CHEMBL5148467

实验名称：Inhibition of CYP2C9 (unknown origin) expressed in baculovirus-infected insect cells ... 来源：ChEMBL 靶标：Cytochrome P450 2C9 External Id：CHEMBL5148468

实验名称：Inhibition of CYP2C19 (unknown origin) expressed in baculovirus-infected insect cells... 来源：ChEMBL 靶标：Cytochrome P450 2C19 External Id：CHEMBL5148469

实验名称：Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei Liste... 来源：ChEMBL 靶标：Trypanosoma brucei brucei External Id：CHEMBL5148462

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