格列派特

• 常用名: 格列派特
• 英文名: Glisoxepid
• CAS号: 25046-79-1
• 分子量: 449.52400
• 密度: 1.37g/cm3
• 沸点: N/A
• 分子式: C₂₀H₂₇N₅O₅S
• 熔点: N/A
• 闪点: N/A

格列派特用途

Glisoxepide 是一种磺胺衍生物,是一种可口服的,非选择性的 K(ATP) 通道阻滞剂,具有抗高血糖活性和心血管调节作用。

格列派特名称

• 中文名: 格列派特
• 英文名: N-[2-[4-(azepan-1-ylcarbamoylsulfamoyl)phenyl]ethyl]-5-methyl-1,2-oxazole-3-carboxamide

格列派特生物活性

• 描述: Glisoxepide 是一种磺胺衍生物,是一种可口服的,非选择性的 K(ATP) 通道阻滞剂,具有抗高血糖活性和心血管调节作用。
• 相关类别:
  研究领域 >> 心血管疾病
  研究领域 >> 代谢疾病
  信号通路 >> 跨膜转运 >> 钾通道
• 靶点实验:

  K(ATP) channel[1]

• 体外研究: glishoxepide抑制大鼠肝细胞摄取胆汁酸[3]。glishoxepide以200μM的Ki非竞争性地抑制胆酸的摄取[3]。
• 参考文献:

  [1]. Sato T, et al. Bepridil, an antiarrhythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection. J Pharmacol Exp Ther. 2006 Jan;316(1):182-8. Epub 2005 Sep 20.

  [2]. Selvaag E. Photohemolytic potency of oral antidiabetic drugs in vitro: effects of antioxidants and a nitrogen atmosphere. Photodermatol Photoimmunol Photomed. 1996 Aug;12(4):166-70.

  [3]. Fückel D, et al. Interaction of sulfonylureas with the transport of bile acids into hepatocytes. Eur J Pharmacol. 1992 Mar 31;213(3):393-404.

格列派特物理化学性质

• 密度: 1.37g/cm3
• 分子式: C₂₀H₂₇N₅O₅S
• 分子量: 449.52400
• 精确质量: 449.17300
• PSA: 142.02000
• LogP: 3.92580
• InChIKey: ZKUDBRCEOBOWLF-UHFFFAOYSA-N
• SMILES: Cc1cc(C(=O)NCCc2ccc(S(=O)(=O)NC(=O)NN3CCCCCC3)cc2)no1
• 折射率: 1.617

格列派特毒性和生态

格列派特靶点实验

查看更多实验

实验名称：qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signa... 来源：824 靶标：AR protein [Homo sapiens] External Id：MDAN535

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：qHTS assay to identify small molecule antagonists of the androgen receptor (AR) sign... 来源：824 靶标：N/A External Id：MDAV150

实验名称：qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cel... 来源：824 靶标：RecName: Full=ATPase family AAA domain-containing protein 5; AltName: Full=Chromosome fragility-associated gene 1 protein External Id：ELG271

实验名称：Choleostatic liver toxicity, either proven histopathologically or where the ratio of ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137727

实验名称：Severe hepatitis, defined as possibly life-threatening liver failure or through clini... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137728

实验名称：qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signal... 来源：824 靶标：thyroid hormone receptor beta isoform 2 [Rattus norvegicus] External Id：TRN186

实验名称：Chronic liver disease either proven histopathologically, or through a chonic elevatio... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137729

实验名称：qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signal... 来源：824 靶标：N/A External Id：TRV455

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格列派特英文别名

• Glisoxepida [INN-Spanish]
• Glisepin
• Glisoxepida
• Glisoxepid
• Glisoxepide
• 5-methyl-isoxazole-3-carboxylic acid 4-(azepan-1-ylcarbamoyl-sulfamoyl)-phenethylamide
• Glisoxepida [Spanish]
• N-{2-[4-({[(azepan-1-ylamino)carbonyl]amino}sulfonyl)phenyl]ethyl}-5-methylisoxazole-3-carboxamide
• Glisoxepidum
• Glisoxepidum [INN-Latin]
• N-{2-[4-({[(azepan-1-yIamino)carbonyI]amino}suIfonyl)phenyI]ethyI}-5-methylisoxazole-3-carboxamide
• Glisoxepide (INN)
• Pro-Diaban