20S,24R-环氧基-达马树脂-12,25-二醇-3-酮

• 常用名: 20S,24R-环氧基-达马树脂-12,25-二醇-3-酮
• 英文名: 20s,24r-epoxydammar-12,25-diol-3-one
• CAS号: 25279-15-6
• 分子量: 474.716
• 密度: 1.1±0.1 g/cm3
• 沸点: 561.9±45.0 °C at 760 mmHg
• 分子式: C₃₀H₅₀O₄
• 熔点: N/A
• 闪点: 173.0±22.2 °C

用途

A novel Notch inhibitor that reduces protein expression of NOTCH1, NICD and HES1 in HEK293 cells and downregulates Notch target genes.

20S,24R-环氧基-达马树脂-12,25-二醇-3-酮名称

• 中文名: 20S,24R-环氧基-达马树脂-12,25-二醇-3-酮
• 英文名: (5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-((2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-3H-cyclopenta[a]phenanthren-3-one

20S,24R-环氧基-达马树脂-12,25-二醇-3-酮物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 561.9±45.0 °C at 760 mmHg
• 分子式: C₃₀H₅₀O₄
• 分子量: 474.716
• 闪点: 173.0±22.2 °C
• 精确质量: 474.370911
• PSA: 66.76000
• LogP: 5.45
• InChIKey: MOCDJPYINJXPKU-GURBVUPCSA-N
• SMILES: CC(C)(O)C1CCC(C)(C2CCC3(C)C2C(O)CC2C4(C)CCC(=O)C(C)(C)C4CCC23C)O1
• 外观性状: 晶体
• 蒸汽压: 0.0±3.5 mmHg at 25°C
• 折射率: 1.527
• 储存条件: 2-8℃，干燥，密闭

20S,24R-环氧基-达马树脂-12,25-二醇-3-酮安全信息

• 危害码 (欧洲): Xi

20S,24R-环氧基-达马树脂-12,25-二醇-3-酮靶点实验

查看更多实验

实验名称：Retention time of the compound in mixed human liver microsomes treated with 20(S)-pro... 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3541027

实验名称：Antibacterial activity against Acinetobacter baumannii by dilution technique 来源：ChEMBL 靶标：Acinetobacter baumannii External Id：CHEMBL2427270

实验名称：Cytotoxicity against LPS-stimulated mouse RAW264.7 cells at 20 uM after 24 hrs by MTT... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4605615

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4605616

实验名称：Drug excretion in Sprague-Dawley rat feces treated with 20(S)-protopanaxadiol at 100 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3527668

实验名称：Drug level in human hepatocytes treated with 20(S)-protopanaxadiol at 50 uM after 180... 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL3530889

实验名称：Antibacterial activity against Bacillus subtilis 168 by dilution technique 来源：ChEMBL 靶标：Bacillus subtilis External Id：CHEMBL2427281

实验名称：Antibacterial activity against Pseudomonas aeruginosa by dilution technique 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL2427269

实验名称：Antibacterial activity against Escherichia coli by dilution technique 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL2427268

实验名称：Antibacterial activity against Staphylococcus aureus RN4220 by dilution technique 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL2427282

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20S,24R-环氧基-达马树脂-12,25-二醇-3-酮英文别名

• (12β,24R)-12,25-Dihydroxy-20,24-epoxydammaran-3-one