FTO-IN-8

• 常用名: FTO-IN-8
• 英文名: FTO-IN-8
• CAS号: 2640366-38-5
• 分子量: 346.85
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₂₃ClN₂O₂
• 熔点: N/A
• 闪点: N/A

FTO-IN-8用途

FTO-IN-8(FTO-43)是一种N6甲基腺苷去甲基化酶(FTO)(脂肪质量和肥胖相关蛋白)抑制剂,IC50值为5.5μM。FTO-IN-8具有抗癌细胞增殖活性[1]。

FTO-IN-8名称

• 英文名: FTO-IN-8

FTO-IN-8生物活性

• 描述: FTO-IN-8(FTO-43)是一种N6甲基腺苷去甲基化酶(FTO)(脂肪质量和肥胖相关蛋白)抑制剂,IC50值为5.5μM。FTO-IN-8具有抗癌细胞增殖活性[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 体外研究: FTO-IN-8(FTO-43)(0-50μM,24-72小时)抑制癌细胞增殖,对正常结肠细胞无细胞毒性[1]。FTO-IN-8(FTO-43)可增加胃癌AGS细胞中的m 6 A和m 6 A m水平,并抑制Wnt/PI3K-Akt信号[1]。细胞活力测定[1]细胞系：AGS、SNU16和KATOII细胞系浓度：0-50μM孵育时间：24、48、72小时结果：抑制SNU16、KATOII和AGS的生长,EC50值分别为17.7μM、35.9μM和20.3μM。
• 参考文献:

  [1]. Sarah Huff, et al. Rational Design and Optimization of m6A-RNA Demethylase FTO Inhibitors as Anticancer Agents. J Med Chem. 2022 Aug 8.

FTO-IN-8物理化学性质

• 分子式: C₁₉H₂₃ClN₂O₂
• 分子量: 346.85
• InChIKey: QHNARTNMADDQGU-UHFFFAOYSA-N
• SMILES: Clc1ccccc1-c1ccc(CNCC2(N3CCCC3)COC2)o1

FTO-IN-8靶点实验

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实验名称：Inhibition of FTO in human AGS cells assessed as downregulation of wnt signaling by m... 来源：ChEMBL 靶标：Alpha-ketoglutarate-dependent dioxygenase FTO External Id：CHEMBL5142395

实验名称：Inhibition of FTO in human AGS cells assessed as downregulation of wnt signaling by m... 来源：ChEMBL 靶标：Alpha-ketoglutarate-dependent dioxygenase FTO External Id：CHEMBL5142396

实验名称：Inhibition of FTO in human AGS cells assessed as downregulation of pI3K-Akt signaling... 来源：ChEMBL 靶标：Alpha-ketoglutarate-dependent dioxygenase FTO External Id：CHEMBL5142397

实验名称：Inhibition of FTO in human AGS cells assessed as upregulation of m6A level by LC-MS/M... 来源：ChEMBL 靶标：Alpha-ketoglutarate-dependent dioxygenase FTO External Id：CHEMBL5142393

实验名称：Inhibition of FTO in human AGS cells assessed as upregulation of m6Am level by LC-MS/... 来源：ChEMBL 靶标：Alpha-ketoglutarate-dependent dioxygenase FTO External Id：CHEMBL5142394

实验名称：Cytotoxicity against human SNU-16 cells assessed as reduction in cell viability at 10... 来源：ChEMBL 靶标：SNU-16 External Id：CHEMBL5142387

实验名称：Cytotoxicity against human KATO III stomach cancer cell line assessed as reduction in... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5142388

实验名称：Antiproliferative activity against human AGS cells assessed as reduction in cell viab... 来源：ChEMBL 靶标：AGS External Id：CHEMBL5142383

实验名称：Antiproliferative activity against human SNU-16 cells assessed as reduction in cell v... 来源：ChEMBL 靶标：SNU-16 External Id：CHEMBL5142384

实验名称：Cytotoxicity against human HEK cells assessed as inhibition of proliferation at 30 uM... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5142385

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