hiCE inhibitor-1

• 常用名: hiCE inhibitor-1
• 英文名: hiCE inhibitor-1
• CAS号: 2654-68-4
• 分子量: 457.35
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₄Cl₂N₂O₄S₂
• 熔点: N/A
• 闪点: N/A

hiCE inhibitor-1用途

hiCE抑制剂-1是一种磺酰胺衍生物,是一种选择性人类肠道酶(hiCE)抑制剂,Ki值为53.3 nM。hiCE抑制剂-1可用于改善伊立替康(HY-16562)诱导的腹泻[1]。

hiCE inhibitor-1名称

• 英文名: hiCE inhibitor-1

hiCE inhibitor-1生物活性

• 描述: hiCE抑制剂-1是一种磺酰胺衍生物,是一种选择性人类肠道酶(hiCE)抑制剂,Ki值为53.3 nM。hiCE抑制剂-1可用于改善伊立替康(HY-16562)诱导的腹泻[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Randy M Wadkins, et al. Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity. Mol Pharmacol. 2004 Jun;65(6):1336-43.

hiCE inhibitor-1物理化学性质

• 分子式: C₁₈H₁₄Cl₂N₂O₄S₂
• 分子量: 457.35
• InChIKey: DCKZGFRFXGBGOQ-UHFFFAOYSA-N
• SMILES: O=S(=O)(Nc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1)c1ccc(Cl)cc1

hiCE inhibitor-1靶点实验

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实验名称：Selectivity ratio of Ki for human intestinal CE to Ki for human liver CE1 来源：ChEMBL 靶标：N/A External Id：CHEMBL947850

实验名称：Inhibition of human intestinal CE-mediated irinotecan hydrolysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL947849

实验名称：Inhibition of human BchE using butyrylthiocholine as substrate by spectrophotometric ... 来源：ChEMBL 靶标：Cholinesterase External Id：CHEMBL947852

实验名称：Inhibition of human AchE using acetylthiocholine as substrate by spectrophotometric m... 来源：ChEMBL 靶标：Acetylcholinesterase External Id：CHEMBL947851

实验名称：Growth inhibition of doxorubicin-sensitive human MCF7 cells after 24 hrs in presence ... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL926769

实验名称：Inhibition of human liver CE1-mediated O-nitrophenyl acetate hydrolysis by spectropho... 来源：ChEMBL 靶标：Liver carboxylesterase 1 External Id：CHEMBL947848

实验名称：Inhibition of human intestinal CE-mediated O-nitrophenyl acetate hydrolysis by spectr... 来源：ChEMBL 靶标：N/A External Id：CHEMBL947847

实验名称：Growth inhibition of doxorubicin-sensitive human MCF7 cells after 24 hrs 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL927747

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