EBOV/MARV-IN-3

• 常用名: EBOV/MARV-IN-3
• 英文名: EBOV/MARV-IN-3
• CAS号: 2687245-05-0
• 分子量: 534.52
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₂₉F₃N₂O₆
• 熔点: N/A
• 闪点: N/A

EBOV/MARV-IN-3用途

EBOV/MARV-IN-3(化合物32)是一种有效的EBOV和MARV抑制剂,IC50值分别为0.5和1.2µM。EBOV/MARV-IN-3与靠近EBOV Y517的疏水性口袋结合。EBOV/MARV-IN-3显示出抗病毒活性[1]。

EBOV/MARV-IN-3名称

• 英文名: EBOV/MARV-IN-3

EBOV/MARV-IN-3生物活性

• 描述: EBOV/MARV-IN-3(化合物32)是一种有效的EBOV和MARV抑制剂,IC50值分别为0.5和1.2µM。EBOV/MARV-IN-3与靠近EBOV Y517的疏水性口袋结合。EBOV/MARV-IN-3显示出抗病毒活性[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 丝状病毒
• 靶点实验:

  IC50: 0.5 µM (EBOV); 1.2 µM (MARV)[1]

• 参考文献:

  [1]. Gao Y, et al. Development of coumarine derivatives as potent anti-filovirus entry inhibitors targeting viral glycoprotein. Eur J Med Chem. 2020 Oct 15;204:112595.

EBOV/MARV-IN-3物理化学性质

• 分子式: C₂₇H₂₉F₃N₂O₆
• 分子量: 534.52
• InChIKey: JZHFBYJXKDDCIX-UHFFFAOYSA-N
• SMILES: Cc1c(Cc2ccc(OC(F)(F)F)cc2)c(=O)oc2cc(OCC(O)CN3CCC(C(N)=O)CC3)ccc12

EBOV/MARV-IN-3靶点实验

查看更多实验

实验名称：Selectivity index, ratio of CC50 for human A549 cells to IC50 for inhibition of envel... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4772706

实验名称：Inhibition of envelope glycoprotein N61A mutant in HIV pseudotyped Zaire Ebolavirus i... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4772707

实验名称：Cytotoxicity against human A549 cells assessed as reduction in cell viability by Cell... 来源：ChEMBL 靶标：A549 External Id：CHEMBL4772704

实验名称：Selectivity index, ratio of CC50 for human A549 cells to IC50 for inhibition of envel... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4772705

实验名称：Inhibition of envelope glycoprotein D522A mutant in HIV pseudotyped Zaire Ebolavirus ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4772708

实验名称：Antiviral activity against pseudotyped Ebola virus assessed as inhibition of viral en... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5118632

实验名称：Selectivity index, ratio of IC50 for inhibition of envelope glycoprotein Y517S mutant... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4772709

实验名称：Inhibition of envelope glycoprotein in HIV pseudotyped Zaire Ebolavirus infected in h... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4772702

实验名称：Inhibition of envelope glycoprotein in HIV pseudotyped Marburgvirus infected in human... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4772703

实验名称：Inhibition of envelope glycoprotein N61D mutant in HIV pseudotyped Zaire Ebolavirus i... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4772700

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