STING PROTAC SP23

• 常用名: STING PROTAC SP23
• 英文名: STING PROTAC SP23
• CAS号: 2762552-74-7
• 分子量: 699.677
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₄H₃₃N₇O₁₀
• 熔点: N/A
• 闪点: N/A

STING PROTAC SP23用途

SP23是一种基于小分子STING抑制剂(C-170)和泊马利度胺(一种CRBN配体)的STING蛋白降解剂(PROTAC),显示出降解效力,DC50为3.2μm。SP23通过调节STING信号通路在顺铂诱导的急性肾损伤小鼠模型中发挥了很高的抗炎作用。

STING PROTAC SP23名称

• 英文名: STING PROTAC SP23

STING PROTAC SP23生物活性

• 描述: SP23是一种基于小分子STING抑制剂(C-170)和泊马利度胺(一种CRBN配体)的STING蛋白降解剂(PROTAC),显示出降解效力,DC50为3.2μm。SP23通过调节STING信号通路在顺铂诱导的急性肾损伤小鼠模型中发挥了很高的抗炎作用。
• 参考文献: 1. Jin Liu, et al. J Med Chem. 2022 Apr 22. doi: 10.1021/acs.jmedchem.1c01948.

STING PROTAC SP23物理化学性质

• 分子式: C₃₄H₃₃N₇O₁₀
• 分子量: 699.677
• InChIKey: TXNQXRGOKABDOB-FOCLMDBBSA-N
• SMILES: O=C(C=CC(=O)Nc1ccc(NC(=O)c2ccc([N+](=O)[O-])o2)cc1)NCCCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O

STING PROTAC SP23靶点实验

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实验名称：Induction of PI3K protein degradation in human THP-1 cells at 1.25 to 20 uM incubated... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5165981

实验名称：Induction of STAT3 protein degradation in human THP-1 cells at 1.25 to 20 uM incubate... 来源：ChEMBL 靶标：Signal transducer and activator of transcription 3 External Id：CHEMBL5165980

实验名称：Induction of TLR4 protein degradation in human THP-1 cells at 1.25 to 20 uM incubated... 来源：ChEMBL 靶标：Toll-like receptor 4 External Id：CHEMBL5165983

实验名称：Induction of AKT protein degradation in human THP-1 cells at 1.25 to 20 uM incubated ... 来源：ChEMBL 靶标：RAC-alpha serine/threonine-protein kinase External Id：CHEMBL5165982

实验名称：Renal protective activity against cisplatin-induced acute kidney injury in C57BL/6J m... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5165977

实验名称：Renal protective activity against cisplatin-induced acute kidney injury in C57BL/6J m... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5165976

实验名称：Induction of JAK2 protein degradation in human THP-1 cells at 1.25 to 20 uM incubated... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK2 External Id：CHEMBL5165979

实验名称：Renal protective activity against cisplatin-induced acute kidney injury in C57BL/6J m... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5165978

实验名称：Toxicity in cisplatin-induced acute kidney injury in C57BL/6J mouse model assessed as... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5165973

实验名称：Toxicity in cisplatin-induced acute kidney injury in C57BL/6J mouse model assessed as... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5165972

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