STING PROTAC SP23
Modify Date: 2025-09-10 12:33:39
STING PROTAC SP23 structure
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Common Name | STING PROTAC SP23 | ||
|---|---|---|---|---|
| CAS Number | 2762552-74-7 | Molecular Weight | 699.677 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C34H33N7O10 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of STING PROTAC SP23SP23 is a STING protein degrader (PROTAC) based on a small-molecule STING inhibitor (C-170) and pomalidomide (a CRBN ligand), shows degradation potency with DC50 of 3.2 uM.SP23 exerted high anti-inflammatory efficacy in a cisplatin-induced acute kidney injury mouse model by modulating the STING signaling pathway. |
| Name | STING PROTAC SP23 |
|---|
| Description | SP23 is a STING protein degrader (PROTAC) based on a small-molecule STING inhibitor (C-170) and pomalidomide (a CRBN ligand), shows degradation potency with DC50 of 3.2 uM.SP23 exerted high anti-inflammatory efficacy in a cisplatin-induced acute kidney injury mouse model by modulating the STING signaling pathway. |
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| References | 1. Jin Liu, et al. J Med Chem. 2022 Apr 22. doi: 10.1021/acs.jmedchem.1c01948. |
| Molecular Formula | C34H33N7O10 |
|---|---|
| Molecular Weight | 699.677 |