PfGSK3/PfPK6-IN-2

• 常用名: PfGSK3/PfPK6-IN-2
• 英文名: PfGSK3/PfPK6-IN-2
• CAS号: 2797225-47-7
• 分子量: 502.46
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₅Cl₂N₅OS
• 熔点: N/A
• 闪点: N/A

PfGSK3/PfPK6-IN-2用途

PfGSK3/PfPK6-IN-2是一种有效的双PfGSK2/PfPK6(恶性疟原虫GSK3/PK6)抑制剂(IC50:172nM和11nM)。PfGSK3/PfPK6-IN-2可用于疟疾研究[1]。

PfGSK3/PfPK6-IN-2名称

• 英文名: PfGSK3/PfPK6-IN-2

PfGSK3/PfPK6-IN-2生物活性

• 描述: PfGSK3/PfPK6-IN-2是一种有效的双PfGSK2/PfPK6(恶性疟原虫GSK3/PK6)抑制剂(IC50:172nM和11nM)。PfGSK3/PfPK6-IN-2可用于疟疾研究[1]。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> GSK-3
  研究领域 >> 感染
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> GSK-3
• 靶点实验:

  Plasmodium falciparum GSK3/PK6 (PfGSK3/PfPK6)[1]

• 体外研究: PfGSK3/PfPK6-IN-2(化合物23d)抑制红细胞中恶性疟原虫3D7负载(EC50:552nM)[1]。PfGSK3/PfPK6-IN-2(2μM)显示出对HepG2细胞的细胞毒性[1]。

PfGSK3/PfPK6-IN-2物理化学性质

• 分子式: C₂₄H₂₅Cl₂N₅OS
• 分子量: 502.46

PfGSK3/PfPK6-IN-2靶点实验

查看更多实验

实验名称：Selectivity index, ratio of CC50 for human HepG2 cells to EC50 for Plasmodium berghei 来源：ChEMBL 靶标：N/A External Id：CHEMBL5107055

实验名称：Kinetic solubility of the compound in PBS buffer at pH 7.4 来源：ChEMBL 靶标：N/A External Id：CHEMBL5107051

实验名称：Cytotoxicity against human HepG2 cells assessed as reduction in cell viability at 200... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL5107046

实验名称：Cytotoxicity against human HepG2 cells assessed as reduction in cell viability at 2 u... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL5107047

实验名称：Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocy... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL5107048

实验名称：Inhibition of Plasmodium falciparum GSK3 measured after 2 hrs by luciferin-based lumi... 来源：ChEMBL 靶标：Glycogen synthase kinase 3 External Id：CHEMBL5107042

实验名称：Inhibition of Plasmodium falciparum PK6 measured after 2 hrs by luciferin-based lumin... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5107043

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