Antiparasitic agent-18

• 常用名: Antiparasitic agent-18
• 英文名: Antiparasitic agent-18
• CAS号: 2821884-59-5
• 分子量: 435.48
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₁N₇O
• 熔点: N/A
• 闪点: N/A

Antiparasitic agent-18用途

Antiparasitic agent-18 (compound 3a) 对 T. brucei (EC50=0.4 μM)、T. cruzi (EC50=0.21 μM) 和 L. donovani (EC50=0.26 μM) 具有活性和选择性。Antiparasitic agent-18 具有有效的抗原虫活性。

Antiparasitic agent-18名称

• 英文名: Antiparasitic agent-18

Antiparasitic agent-18生物活性

• 描述: Antiparasitic agent-18 (compound 3a) 对 T. brucei (EC50=0.4 μM)、T. cruzi (EC50=0.21 μM) 和 L. donovani (EC50=0.26 μM) 具有活性和选择性。Antiparasitic agent-18 具有有效的抗原虫活性。
• 相关类别:
  研究领域 >> 感染
• 参考文献:

  [1]. J Jonathan Nué-Martinez, et al. Synthesis and Biophysical and Biological Studies of N-Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites. J Med Chem. 2023 Oct 12;66(19):13452-13480.

Antiparasitic agent-18物理化学性质

• 分子式: C₂₅H₂₁N₇O
• 分子量: 435.48

Antiparasitic agent-18靶点实验

查看更多实验

实验名称：Selectivity index, ratio of CC50 for cytotoxicity against HEK cells to EC50 for antit... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5368996

实验名称：Antiparasitic activity against Trichomonas vaginalis JH31A#4 assessed as inhibition o... 来源：ChEMBL 靶标：Trichomonas vaginalis External Id：CHEMBL5368993

实验名称：Selectivity index, ratio of CC50 for cytotoxicity against human THP-1 cells to EC50 f... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5368992

实验名称：Antileishmanial activity against Leishmania donovani MHOM/ET/67/HU3 intracellular ama... 来源：ChEMBL 靶标：Leishmania donovani External Id：CHEMBL5368989

实验名称：Cytotoxicity against human THP-1 cells assessed as reduction in cell viability by MTT... 来源：ChEMBL 靶标：THP-1 External Id：CHEMBL5368990

实验名称：Selectivity index, ratio of CC50 for cytotoxicity against mouse L929 cells to EC50 fo... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5368987

实验名称：Antileishmanial activity against Leishmania donovani MHOM/ET/67/HU3 promastigotes ass... 来源：ChEMBL 靶标：Leishmania donovani External Id：CHEMBL5368988

实验名称：Cytotoxicity against mouse L929 cells incubated for 72 hrs by fluorescence based micr... 来源：ChEMBL 靶标：L929 External Id：CHEMBL5368985

实验名称：Selectivity index, ratio of CC50 for cytotoxicity against mouse L929 cells to EC50 fo... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5368986

实验名称：Antitrypanosomal activity against Trypanosoma cruzi epimastigotes CL-B5 expressing la... 来源：ChEMBL 靶标：Trypanosoma cruzi External Id：CHEMBL5368983

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