补骨脂查耳酮

• 常用名: 补骨脂查耳酮
• 英文名: Bavachalcone
• CAS号: 28448-85-3
• 分子量: 324.370
• 密度: 1.2±0.1 g/cm3
• 沸点: 549.6±50.0 °C at 760 mmHg
• 分子式: C₂₀H₂₀O₄
• 熔点: 168-169℃
• 闪点: 300.2±26.6 °C

补骨脂查耳酮用途

补骨脂查尔酮(Bavachalcone)是从补骨脂中分离的化合物,广泛用于中药,具有抗生素和抗癌等活性。

补骨脂查耳酮名称

• 中文名: 补骨脂查耳酮
• 英文名: (E)-1-[2,4-dihydroxy-5-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
• 中文别名: 补骨脂查尔酮 | 补骨酯查儿酮

补骨脂查耳酮生物活性

• 描述: 补骨脂查尔酮(Bavachalcone)是从补骨脂中分离的化合物,广泛用于中药,具有抗生素和抗癌等活性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
  天然产物 >> 黄酮类化合物
• 参考文献:

  [1]. Park CK, et al. Bavachalcone inhibits osteoclast differentiation through suppression of NFATc1 induction by RANKL. Biochem Pharmacol. 2008 Jun 1;75(11):2175-82.

  [2]. Choi YH, et al. In vitro BACE-1 inhibitory phenolic components from the seeds of Psoralea corylifolia. Planta Med. 2008 Sep;74(11):1405-8.

  [3]. Shan L, et al. Comparison of the Inhibitory Potential of Bavachalcone and Corylin against UDP-Glucuronosyltransferases. Evid Based Complement Alternat Med. 2014;2014:958937.

补骨脂查耳酮物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 549.6±50.0 °C at 760 mmHg
• 熔点: 168-169℃
• 分子式: C₂₀H₂₀O₄
• 分子量: 324.370
• 闪点: 300.2±26.6 °C
• 精确质量: 324.136169
• PSA: 77.76000
• LogP: 5.21
• InChIKey: BLZGPHNVMRXDCB-UXBLZVDNSA-N
• SMILES: CC(C)=CCc1cc(C(=O)C=Cc2ccc(O)cc2)c(O)cc1O
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.658
• 储存条件: -20°C

补骨脂查耳酮靶点实验

查看更多实验

实验名称：Inhibition of aromatase from human placental microsomes 来源：ChEMBL 靶标：Aromatase External Id：CHEMBL949646

实验名称：Antibacterial activity Micrococcus luteus NBRC 333 assessed as inhibition of bacteria... 来源：ChEMBL 靶标：Micrococcus luteus External Id：CHEMBL5233600

实验名称：HIV Cellular Data 来源：NIAID 靶标：N/A External Id：HIV Cellular Data

实验名称：Antibacterial activity Staphylococcus epidermidis NBRC 12993 assessed as inhibition o... 来源：ChEMBL 靶标：Staphylococcus epidermidis External Id：CHEMBL5233599

实验名称：Antibacterial activity Bacillus subtilis NBRC 3757 assessed as inhibition of bacteria... 来源：ChEMBL 靶标：Bacillus subtilis External Id：CHEMBL5233598

实验名称：Cytotoxicity against human A549 cells after 48 hrs by MTT assay 来源：ChEMBL 靶标：A549 External Id：CHEMBL3580330

实验名称：Inhibition of baker's yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyrano... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3620092

实验名称：Inhibition of baker's yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyrano... 来源：ChEMBL 靶标：Alpha-glucosidase MAL62 External Id：CHEMBL3047160

实验名称：Induction of DNA damage in human SU8686 cells assessed as increase in gammaH2AX phosp... 来源：ChEMBL 靶标：SU.86.86 External Id：CHEMBL4627631

实验名称：Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay 来源：ChEMBL 靶标：K562 External Id：CHEMBL3412606

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补骨脂查耳酮英文别名

• (2E)-1-[2,4-Dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
• Bavachalcone
• (E)-1-(2,4-Dihydroxy-5-(3-methyl-but-2-enyl)-phenyl)-3-(4-hydroxy-phenyl)-propenone
• buroussochalcone B
• broussochalcone B