JG-2016

更新时间：2025-09-27 17:03:00

JG-2016结构式	常用名	JG-2016	英文名	JG-2016
	CAS号	2887480-87-5	分子量	376.84
	密度	N/A	沸点	N/A
	分子式	C₁₈H₂₁ClN₄O₃	熔点	N/A
	MSDS	N/A	闪点	N/A

JG-2016用途

JG-2016 是一种有效的组蛋白乙酰转移酶 1 (HAT1) 抑制剂,在 HAT1 乙酰化检测中 IC50 为 14.8 μM[1]。

英文名	JG-2016

描述	JG-2016 是一种有效的组蛋白乙酰转移酶 1 (HAT1) 抑制剂,在 HAT1 乙酰化检测中 IC50 为 14.8 μM[1]。
相关类别	研究领域 >> 癌症信号通路 >> 表观遗传学 >> 组蛋白乙酰转移酶
参考文献	[1]. Joshua James GRUBER, et al. Modulators of histone acetyltransferase 1 and methods of treatment thereof. Patent, WO2022272313A1.

分子式	C₁₈H₂₁ClN₄O₃
分子量	376.84
InChIKey	IOHJEWFKBRNJIO-UHFFFAOYSA-N
SMILES	CCc1cc2c(cc1Cl)nc1c(=O)[nH]c(=O)nc-1n2CCOCC(C)C

实验名称：Toxicity in mouse assessed as signs of distress at 500 mg/kg, ip administered as sing...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5384644

实验名称：Terminal elimination half life in CD1 mouse at 100 mg/kg, ip measured after 15 to 432...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5384645

实验名称：Inhibition of HAT-1 in EGF-starved human hTERT-HME1 cells assessed as inhibition of H...
来源：ChEMBL
靶标：Histone acetyltransferase type B catalytic subunit
External Id：CHEMBL5384642

实验名称：Toxicity in mouse assessed as drug tolerance up to 250 mg/kg, ip administered as sing...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5384643

实验名称：Inhibition of HAT-1 in human hTERT-HME1 cells assessed as inhibition of H4 lysine 12 ...
来源：ChEMBL
靶标：Histone acetyltransferase type B catalytic subunit
External Id：CHEMBL5384640

实验名称：Inhibition of HAT-1 in human hTERT-HME1 cells assessed as inhibition of H4 lysine 5 a...
来源：ChEMBL
靶标：Histone acetyltransferase type B catalytic subunit
External Id：CHEMBL5384639

实验名称：Inhibition of FAD-dependent oxidase (unknown origin)
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5384666

实验名称：Binding affinity to HAT-1 in forskolin treated human A549 cells assessed as thermal s...
来源：ChEMBL
靶标：Histone acetyltransferase type B catalytic subunit
External Id：CHEMBL5384632

实验名称：Selectivity index, ratio of IC50 for inhibition of human p300 to IC50 for inhibition ...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5384664

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