RET-IN-22

• 常用名: RET-IN-22
• 英文名: RET-IN-22
• CAS号: 2918281-79-3
• 分子量: 584.59
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₃₁F₃N₆O₄
• 熔点: N/A
• 闪点: N/A

RET-IN-22用途

RET-IN-22(化合物17b)是一种强效、选择性和口服活性的RET抑制剂,野生型RET和RET-V804M的IC50分别为20.9nM和18.3nM。RET-IN-22对大多数激酶显示出高度选择性,尤其是对EGFR和VEGFR2。RET-IN-22具有抗癌作用[1]。

RET-IN-22名称

• 英文名: RET-IN-22

RET-IN-22生物活性

• 描述: RET-IN-22(化合物17b)是一种强效、选择性和口服活性的RET抑制剂,野生型RET和RET-V804M的IC50分别为20.9nM和18.3nM。RET-IN-22对大多数激酶显示出高度选择性,尤其是对EGFR和VEGFR2。RET-IN-22具有抗癌作用[1]。
• 相关类别:
  研究领域 >> 癌症
• 靶点实验:

  IC50: 20.9 nM (wild-type RET) and 18.3 nM (RET-V804M)[1]

• 参考文献:

  [1]. Kaifu Wu, et al. Discovery of 3,5-diaryl-1H-pyrazol-based ureas as potent RET inhibitors. Eur J Med Chem. 2023 May 5;251:115237.

RET-IN-22物理化学性质

• 分子式: C₂₉H₃₁F₃N₆O₄
• 分子量: 584.59

RET-IN-22靶点实验

查看更多实验

实验名称：Inhibition of RET signalling pathway in mouse BaF3 cells harboring CCDC6-RET-G810C mu... 来源：ChEMBL 靶标：Proto-oncogene tyrosine-protein kinase receptor Ret External Id：CHEMBL5349061

实验名称：AUC (0 to infinity) in Sprague-Dawley rat at 5 mg/kg, iv 来源：ChEMBL 靶标：N/A External Id：CHEMBL5349062

实验名称：Inhibition of RET signalling pathway in mouse BaF3 cells harboring CCDC6-RET-G810C mu... 来源：ChEMBL 靶标：Proto-oncogene tyrosine-protein kinase receptor Ret External Id：CHEMBL5349059

实验名称：Inhibition of RET signalling pathway in mouse BaF3 cells harboring CCDC6-RET-G810C mu... 来源：ChEMBL 靶标：Proto-oncogene tyrosine-protein kinase receptor Ret External Id：CHEMBL5349060

实验名称：Inhibition of RET signalling pathway in mouse BaF3 cells harboring CCDC6-RET assessed... 来源：ChEMBL 靶标：Proto-oncogene tyrosine-protein kinase receptor Ret External Id：CHEMBL5349057

实验名称：Inhibition of RET signalling pathway in mouse BaF3 cells harboring CCDC6-RET-V804M mu... 来源：ChEMBL 靶标：Proto-oncogene tyrosine-protein kinase receptor Ret External Id：CHEMBL5349058

实验名称：Inhibition of RET signalling pathway in mouse BaF3 cells harboring CCDC6-RET-V804M mu... 来源：ChEMBL 靶标：Proto-oncogene tyrosine-protein kinase receptor Ret External Id：CHEMBL5349055

实验名称：Inhibition of RET signalling pathway in mouse BaF3 cells harboring CCDC6-RET-G810C mu... 来源：ChEMBL 靶标：Proto-oncogene tyrosine-protein kinase receptor Ret External Id：CHEMBL5349056

实验名称：Inhibition of RET signalling pathway in mouse BaF3 cells harboring CCDC6-RET assessed... 来源：ChEMBL 靶标：Proto-oncogene tyrosine-protein kinase receptor Ret External Id：CHEMBL5349054

实验名称：Antiproliferative activity against mouse BaF3 cells incubated for 72 hrs by CCK8 assa... 来源：ChEMBL 靶标：BaF3 External Id：CHEMBL5349045

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