GPR139 agonist-2

• 常用名: GPR139 agonist-2
• 英文名: GPR139 agonist-2
• CAS号: 2983118-29-0
• 分子量: 380.32
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₅F₃N₄O₃
• 熔点: N/A
• 闪点: N/A

GPR139 agonist-2用途

GPR139 agonist-2 (compound 20a) 是一种有效的 GPR139 激动剂,EC50 为 24.7 nM。GPR139 agonist-2 可挽救小鼠精神分裂症模型的社交互动缺陷并减轻认知缺陷。GPR139 agonist-2 具有用于抗精神分裂症药物研究的潜力。

GPR139 agonist-2名称

• 英文名: GPR139 agonist-2

GPR139 agonist-2生物活性

• 描述: GPR139 agonist-2 (compound 20a) 是一种有效的 GPR139 激动剂,EC50 为 24.7 nM。GPR139 agonist-2 可挽救小鼠精神分裂症模型的社交互动缺陷并减轻认知缺陷。GPR139 agonist-2 具有用于抗精神分裂症药物研究的潜力。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> GPR139
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Jianhang Mao, et al. Design and Synthesis of Novel GPR139 Agonists with Therapeutic Effects in Mouse Models of Social Interaction and Cognitive Impairment. J Med Chem. 2023 Oct 26;66(20):14011-14028.

GPR139 agonist-2物理化学性质

• 分子式: C₁₇H₁₅F₃N₄O₃
• 分子量: 380.32

GPR139 agonist-2靶点实验

查看更多实验

实验名称：Tmax in C57BL/6J mouse cerebrospinal fluid at 3 mg/kg, ip measured for 6 hrs by LC-MS... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5373778

实验名称：Tmax in C57BL/6J mouse plasma at 3 mg/kg, ip measured for 6 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5373779

实验名称：Half life in C57BL/6J mouse plasma at 3 mg/kg, ip measured for 6 hrs by LC-MS/MS anal... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5373776

实验名称：Tmax in C57BL/6J mouse brain at 3 mg/kg, ip measured for 6 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5373777

实验名称：Half life in C57BL/6J mouse brain at 3 mg/kg, ip measured for 6 hrs by LC-MS/MS analy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5373774

实验名称：Half life in C57BL/6J mouse cerebrospinal fluid at 3 mg/kg, ip measured for 6 hrs by ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5373775

实验名称：Elimination rate constant in C57BL/6J mouse cerebrospinal fluid at 3 mg/kg, ip measur... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5373772

实验名称：Elimination rate constant in C57BL/6J mouse plasma at 3 mg/kg, ip measured for 6 hrs ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5373773

实验名称：Ratio of AUC (0 to t) in C57BL/6J mouse brain to plasma at 10 mg/kg, ip measured for ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5373770

实验名称：Elimination rate constant in C57BL/6J mouse brain at 3 mg/kg, ip measured for 6 hrs b... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5373771

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