BET-IN-7

• 常用名: BET-IN-7
• 英文名: BET-IN-7
• CAS号: 303985-05-9
• 分子量: 353.83
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₂ClN₃OS
• 熔点: N/A
• 闪点: N/A

BET-IN-7用途

BET-IN-7(化合物1)是一种有效的BET抑制剂,Ki和Kd分别为12.27和89.3μM。BET-IN-7具有研究脓毒症的潜力【1】。

BET-IN-7名称

• 英文名: BET-IN-7

BET-IN-7生物活性

• 描述: BET-IN-7(化合物1)是一种有效的BET抑制剂,Ki和Kd分别为12.27和89.3μM。BET-IN-7具有研究脓毒症的潜力【1】。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 表观遗传学 >> 表观遗传读者域
• 参考文献:

  [1]. Chen X, et al. Discovery of 2-((2-methylbenzyl)thio)-6-oxo-4-(3,4,5-trimethoxyphenyl)-1,6-dihydropyrimidine-5-carbonitrile as a novel and effective bromodomain and extra-terminal (BET) inhibitor for the treatment of sepsis. Eur J Med Chem. 2022 May 8;238:114423

BET-IN-7物理化学性质

• 分子式: C₁₈H₁₂ClN₃OS
• 分子量: 353.83
• InChIKey: XHGLXNUIRLXTQE-UHFFFAOYSA-N
• SMILES: N#Cc1c(-c2ccccc2)nc(SCc2ccccc2Cl)[nH]c1=O

BET-IN-7靶点实验

查看更多实验

实验名称：Inhibition of BRD4 BD1 (57 to 168 residues) (unknown origin) transfected in Escherich... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5114938

实验名称：Inhibition of BRD4 BD2 (352 to 457 residues) (unknown origin) transfected in Escheric... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5114939

实验名称：Inhibition of BRD4 BD1 (unknown origin) using FAM-labeled JQ-1 as fluorescent substra... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5114940

实验名称：AUC (0 to 8 hrs) in Balb/C mouse at 10 umol/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1913249

实验名称：Tmax in Balb/C mouse at 10 umol/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1913248

实验名称：Half life in human liver microsomes in presence of 5'-diphospho-glucuronosyltransfera... 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL1913251

实验名称：Inhibition of BRD4 BD2 (352 to 457 residues) (unknown origin) transfected in Escheric... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5114935

实验名称：Antidiabetic activity in DIO mouse assessed as conversion of dehydrocorticosterone to... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1913250

实验名称：Inhibition of BRD4 BD2 (352 to 457 residues) (unknown origin) transfected in Escheric... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5114937

实验名称：Inhibition of BRD4 BD1 (57 to 168 residues) (unknown origin) transfected in Escherich... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5114931

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