WR-99210

• 常用名: WR-99210
• 英文名: WR99210 hydrochloride
• CAS号: 30711-93-4
• 分子量: 431.14
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₉Cl₄N₅O₂
• 熔点: N/A
• 闪点: N/A

WR-99210用途

WR99210盐酸盐是一种口服活性低毒二氢叶酸还原酶(DHFR)抑制剂(IC50＜0.075nM)。WR99210盐酸盐显示出良好的抗寄生虫活性,对恶性疟原虫和恶性疟原虫株以及弓形虫有效[1][2][3]。

WR-99210名称

• 中文名: WR-99210
• 英文名: 1,3,5-Triazine-2,4-diamine,1,6-dihydro-6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-, hydrochloride(1:1)

WR-99210生物活性

• 描述: WR99210盐酸盐是一种口服活性低毒二氢叶酸还原酶(DHFR)抑制剂(IC50＜0.075nM)。WR99210盐酸盐显示出良好的抗寄生虫活性,对恶性疟原虫和恶性疟原虫株以及弓形虫有效[1][2][3]。
• 相关类别:
  研究领域 >> 感染
• 参考文献:

  [1]. Mui EJ, et al. Triazine Inhibits Toxoplasma gondii tachyzoites in vitro and in vivo. Antimicrob Agents Chemother. 2005 Aug;49(8):3463-7.

  [2]. Hastings MD, et al. Pyrimethamine and WR99210 exert opposing selection on dihydrofolatereductase from Plasmodium vivax. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13137-41.

  [3]. Kiara SM, et al. In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation. Antimicrob Agents Chemother. 2009 Sep;53(9):3793-8.

WR-99210物理化学性质

• 分子式: C₁₄H₁₉Cl₄N₅O₂
• 分子量: 431.14
• InChIKey: VOTSDCGUYAGUNS-UHFFFAOYSA-N
• SMILES: CC1(C)N=C(N)N=C(N)N1OCCCOc1cc(Cl)c(Cl)cc1Cl.Cl

WR-99210靶点实验

查看更多实验

实验名称：ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania ... 来源：ChEMBL 靶标：Glucose transporter External Id：CHEMBL3436044

实验名称：Biochemical screen of P. falciparum CDPK1 来源：1187 靶标：Calcium-Dependent Protein Kinase 1 (CDPK1) External Id：PfalCDPK1

实验名称：ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania ... 来源：ChEMBL 靶标：Solute carrier family 2, facilitated glucose transporter member 1 External Id：CHEMBL3436042

实验名称：Biochemical screen of P. falciparum PK7 来源：1187 靶标：Protein Kinase 7 (PK7) External Id：PfalPK7

实验名称：ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania ... 来源：ChEMBL 靶标：Hexose transporter 1 External Id：CHEMBL3436043

实验名称：Biochemical screen of P. falciparum PK6 来源：1187 靶标：Protein Kinase 6 (PK6) External Id：PfalPK6

实验名称：Biochemical screen of P. falciparum MAPK2 来源：1187 靶标：mitogen-activated protein kinase 2 (MAP2 or MAPK2) External Id：PfalMAPK2

实验名称：Biochemical screen of P. falciparum CDPK4 来源：1187 靶标：Calcium-Dependent Protein Kinase 4 (CDPK4) External Id：PfalCDPK4

实验名称：Inhibition of Plasmodium falciparum DHFR 来源：ChEMBL 靶标：Bifunctional dihydrofolate reductase-thymidylate synthase External Id：CHEMBL4181677

实验名称：Oral bioavailability in Sprague-Dawley rat plasma by LC/MS analysis 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3821962

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