LDN-27219

• 常用名: LDN-27219
• 英文名: LDN 27219
• CAS号: 312946-37-5
• 分子量: 408.497
• 密度: 1.5±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₀H₁₆N₄O₂S₂
• 熔点: N/A
• 闪点: N/A
• 符号: GHS07
• 信号词: Warning

LDN-27219用途

LDN-27219是人组织型转谷氨酰胺酶（hTGase）抑制剂，IC50为600nM。

LDN-27219名称

• 中文名: LDN-27219
• 英文名: LDN-27219

LDN-27219生物活性

• 描述: LDN-27219是人组织型转谷氨酰胺酶(hTGase)抑制剂,IC50为600nM。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 其他
• 参考文献:

  [1]. Case A, et al. Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor. Biochemistry. 2007 Jan 30;46(4):1106-15.

LDN-27219物理化学性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₂₀H₁₆N₄O₂S₂
• 分子量: 408.497
• 精确质量: 408.071472
• LogP: 2.98
• InChIKey: WLBUICQBNZXIDJ-UHFFFAOYSA-N
• SMILES: NNC(=O)CSc1nc2scc(-c3ccccc3)c2c(=O)n1-c1ccccc1
• 折射率: 1.745
• 储存条件: 2-8℃

LDN-27219安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P261-P305 + P351 + P338
• 危险品运输编码: NONH for all modes of transport

LDN-27219靶点实验

查看更多实验

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Inhibitory concentration against tissue transglutaminase was determined using full pr... 来源：ChEMBL 靶标：Protein-glutamine gamma-glutamyltransferase 2 External Id：CHEMBL831130

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Inhibitory concentration against tissue transglutaminase 来源：ChEMBL 靶标：Protein-glutamine gamma-glutamyltransferase 2 External Id：CHEMBL833071

实验名称：HTS to identify compounds that affect the blood-brain barrier permeability in vitro 来源：26908 靶标：N/A External Id：HTS97080

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LDN-27219英文别名

• 2-[(4-Oxo-3,5-diphenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)sulfanyl]acetohydrazide
• Acetic acid, 2-[(3,4-dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]-, hydrazide
• MFCD01943209