IGS-1.76

• 常用名: IGS-1.76
• 英文名: IGS-1.76
• CAS号: 313480-47-6
• 分子量: 358.456
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₂H₁₈N₂OS
• 熔点: N/A
• 闪点: N/A

IGS-1.76用途

IGS-1.76是人NCS-1/Ric8a相互作用的小分子抑制剂,亲和力为1.25 uM(hNCS-1)；表现出比吩噻嗪FD44更高的结合效力,降低异常高的突触数并增强FXS中的联想学习。动物模型。

IGS-1.76名称

• 英文名: N-(1,3-Benzothiazol-2-yl)-3,3-diphenylpropanamide

IGS-1.76生物活性

• 描述: IGS-1.76是人NCS-1/Ric8a相互作用的小分子抑制剂,亲和力为1.25 uM(hNCS-1)；表现出比吩噻嗪FD44更高的结合效力,降低异常高的突触数并增强FXS中的联想学习。动物模型。
• 参考文献: References 1. Roca C, et al. J Med Chem. 2018 Jul 17. doi: 10.1021/acs.jmedchem.8b00088. View Related Products by Target Other Targets

IGS-1.76物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₂₂H₁₈N₂OS
• 分子量: 358.456
• 精确质量: 358.113983
• LogP: 5.65
• InChIKey: GYQWKTIZRYVFEM-UHFFFAOYSA-N
• SMILES: O=C(CC(c1ccccc1)c1ccccc1)Nc1nc2ccccc2s1
• 折射率: 1.700
• 储存条件: -20°C

IGS-1.76靶点实验

查看更多实验

实验名称：Inhibition of human recombinant CK-1delta using casein as substrate at 10 uM after 60... 来源：ChEMBL 靶标：Casein kinase I isoform delta External Id：CHEMBL3239315

实验名称：Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by ... 来源：ChEMBL 靶标：Casein kinase I isoform delta External Id：CHEMBL3239314

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Inhibition of human NCS1 and V5-tagged Ric8a interaction expressed in HEK293 cells at... 来源：ChEMBL 靶标：Synembryn-A External Id：CHEMBL4145364

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IGS-1.76英文别名

• N-(1,3-Benzothiazol-2-yl)-3,3-diphenylpropanamide