IGS-1.76
Modify Date: 2025-09-12 19:29:33
IGS-1.76 structure
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Common Name | IGS-1.76 | ||
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| CAS Number | 313480-47-6 | Molecular Weight | 358.456 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C22H18N2OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IGS-1.76IGS-1.76 is a small molecule inhibitor of human NCS-1/Ric8a interaction with affinity of 1.25 uM (hNCS-1); demonstrates improved binding potency over the phenothiazine FD44, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model. |
| Name | N-(1,3-Benzothiazol-2-yl)-3,3-diphenylpropanamide |
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| Synonym | More Synonyms |
| Description | IGS-1.76 is a small molecule inhibitor of human NCS-1/Ric8a interaction with affinity of 1.25 uM (hNCS-1); demonstrates improved binding potency over the phenothiazine FD44, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model. |
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| References | References 1. Roca C, et al. J Med Chem. 2018 Jul 17. doi: 10.1021/acs.jmedchem.8b00088. View Related Products by Target Other Targets |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C22H18N2OS |
| Molecular Weight | 358.456 |
| Exact Mass | 358.113983 |
| LogP | 5.65 |
| Index of Refraction | 1.700 |
| Storage condition | -20°C |
| Benzenepropanamide, N-2-benzothiazolyl-β-phenyl- |
| N-(1,3-Benzothiazol-2-yl)-3,3-diphenylpropanamide |