N-[4-(2,4-二甲基苯基)-2-噻唑基]苯甲酰胺

• 常用名: N-[4-(2,4-二甲基苯基)-2-噻唑基]苯甲酰胺
• 英文名: INH1
• CAS号: 313553-47-8
• 分子量: 308.40
• 密度: 1.2±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₈H₁₆N₂OS
• 熔点: N/A
• 闪点: N/A

用途

INH1能靶向Hec1/Nek2有丝分裂通路,抑制肿瘤细胞在培养基和动物中的生长。

N-[4-(2,4-二甲基苯基)-2-噻唑基]苯甲酰胺名称

• 中文名: N-[4-(2,4-二甲基苯基)-2-噻唑基]苯甲酰胺
• 英文名: N-[4-(2,4-dimethylphenyl)-1,3-thiazol-2-yl]benzamide,hydrochloride

N-[4-(2,4-二甲基苯基)-2-噻唑基]苯甲酰胺生物活性

• 描述: INH1能靶向Hec1/Nek2有丝分裂通路,抑制肿瘤细胞在培养基和动物中的生长。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
• 参考文献:

  [1]. Wu G, et al. Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Res. 2008 Oct 15;68(20):8393-9.

N-[4-(2,4-二甲基苯基)-2-噻唑基]苯甲酰胺物理化学性质

• 密度: 1.2±0.1 g/cm3
• 分子式: C₁₈H₁₆N₂OS
• 分子量: 308.40
• PSA: 73.72000
• LogP: 5.24
• InChIKey: JPMOKRWIYQGMJL-UHFFFAOYSA-N
• SMILES: Cc1ccc(-c2csc(NC(=O)c3ccccc3)n2)c(C)c1
• 外观性状: 粉末
• 折射率: 1.657
• 储存条件: Desiccate at +4°C

N-[4-(2,4-二甲基苯基)-2-噻唑基]苯甲酰胺靶点实验

查看更多实验

实验名称：Inhibition of cell invasion in human MDA-MB-231 cells assessed as total number of cel... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL2328336

实验名称：Rucaparib conditional oncology-focused drug screen on ovarian cancer cells. 来源：24139 靶标：N/A External Id：Rucaparib conditional drug screen of ovarian cancer cells

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Inhibition of cell migration in human MDA-MB-231 cells assessed as total number of ce... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL2328340

实验名称：Cytotoxicity against human MDA-MB-231 cells assessed as colony formation at 10 uM aft... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL2328339

实验名称：Inhibition of cell migration in human MDA-MB-231 cells assessed as total number of ce... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL2328338

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Anticancer activity against human HeLa cells assessed as reduction of Nek2 level at 2... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL1011551

实验名称：Cytotoxicity against human K562 cells after 4 days by XTT assay 来源：ChEMBL 靶标：K562 External Id：CHEMBL1011548

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

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N-[4-(2,4-二甲基苯基)-2-噻唑基]苯甲酰胺英文别名

• N-[4-(2,4-Dimethylphenyl)-1,3-thiazol-2-yl]benzamide
• Y0392
• INH1
• N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamidehydrochloride