DNMDP

• 常用名: DNMDP
• 英文名: DNMDP
• CAS号: 328104-79-6
• 分子量: 304.344
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₅H₂₀N₄O₃
• 熔点: N/A
• 闪点: N/A

DNMDP用途

DNMDP是一种有效的选择性癌细胞细胞毒性剂,与PDE3A结合,促进PDE3A和Schlafen 12(SLFN12)之间的相互作用；SLFN12与PDE3A的共表达与DNMDP敏感性相关,而SLFN12的消耗导致DNMDP敏感性降低。

DNMDP名称

• 中文名: DNMDP
• 英文名: 6-[4-(Diethylamino)-3-nitrophenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone

DNMDP生物活性

• 描述: DNMDP是一种有效的选择性癌细胞细胞毒性剂,与PDE3A结合,促进PDE3A和Schlafen 12(SLFN12)之间的相互作用；SLFN12与PDE3A的共表达与DNMDP敏感性相关,而SLFN12的消耗导致DNMDP敏感性降低。
• 参考文献: References 1. de Waal L, et al. Nat Chem Biol. 2016 Feb;12(2):102-8. 2. Vandenberghe P, et al. Oncotarget. 2017 Jun 20;8(25):41026-41043. View Related Products by Target Phosphodiesterase (PDE)

DNMDP物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₁₅H₂₀N₄O₃
• 分子量: 304.344
• 精确质量: 304.153534
• LogP: 1.49
• InChIKey: YOSSKNZHADPXJX-UHFFFAOYSA-N
• SMILES: CCN(CC)c1ccc(C2=NNC(=O)CC2C)cc1[N+](=O)[O-]
• 折射率: 1.613
• 储存条件: -20°C

DNMDP靶点实验

查看更多实验

实验名称：Plasma protein binding in human incubated for 5 hrs by UPLC-MS method 来源：ChEMBL 靶标：N/A External Id：CHEMBL5264804

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Microsomal stability in mouse liver microsomes assessed as parent compound remaining ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5264803

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Stability in human plasma assessed as parent compound remaining after 5 hrs 来源：ChEMBL 靶标：N/A External Id：CHEMBL5264806

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Plasma protein binding in mouse incubated for 5 hrs by UPLC-MS method 来源：ChEMBL 靶标：N/A External Id：CHEMBL5264805

实验名称：Selectivity ratio, ratio of IC50 for human PDE3B to EC50 for cytotoxicity against hum... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5264800

实验名称：Selectivity ratio, ratio of IC50 for human PDE3A to EC50 for cytotoxicity against hum... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5264799

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

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DNMDP英文别名

• 6-[4-(Diethylamino)-3-nitrophenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone
• MFCD01829240