DNMDP
Modify Date: 2024-01-05 10:34:12
DNMDP structure
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Common Name | DNMDP | ||
|---|---|---|---|---|
| CAS Number | 328104-79-6 | Molecular Weight | 304.344 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C15H20N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DNMDPDNMDP is a potent and selective cancer cell cytotoxic agent that binds to PDE3A, promotes an interaction between PDE3A and Schlafen 12 (SLFN12); coexpression of SLFN12 with PDE3A correlates with DNMDP sensitivity, whereas depletion of SLFN12 results in decreased DNMDP sensitivity. |
| Name | 6-[4-(Diethylamino)-3-nitrophenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone |
|---|---|
| Synonym | More Synonyms |
| Description | DNMDP is a potent and selective cancer cell cytotoxic agent that binds to PDE3A, promotes an interaction between PDE3A and Schlafen 12 (SLFN12); coexpression of SLFN12 with PDE3A correlates with DNMDP sensitivity, whereas depletion of SLFN12 results in decreased DNMDP sensitivity. |
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| References | References 1. de Waal L, et al. Nat Chem Biol. 2016 Feb;12(2):102-8. 2. Vandenberghe P, et al. Oncotarget. 2017 Jun 20;8(25):41026-41043. View Related Products by Target Phosphodiesterase (PDE) |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C15H20N4O3 |
| Molecular Weight | 304.344 |
| Exact Mass | 304.153534 |
| LogP | 1.49 |
| Index of Refraction | 1.613 |
| Storage condition | -20°C |
| 6-[4-(Diethylamino)-3-nitrophenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone |
| 3(2H)-Pyridazinone, 6-[4-(diethylamino)-3-nitrophenyl]-4,5-dihydro-5-methyl- |
| MFCD01829240 |