木豆异黄酮； 2',4',5-三羟基-7-甲氧基异黄酮

• 常用名: 木豆异黄酮； 2',4',5-三羟基-7-甲氧基异黄酮
• 英文名: Cajanin
• CAS号: 32884-36-9
• 分子量: 300.263
• 密度: 1.5±0.1 g/cm3
• 沸点: 605.5±55.0 °C at 760 mmHg
• 分子式: C₁₆H₁₂O₆
• 熔点: N/A
• 闪点: 231.7±25.0 °C

用途

卡加宁是一种有效的口服活性抗黑素制剂。Cajanin在MNT1细胞中显示出抗增殖活性。木豆苷能有效降低黑色素含量。Cajanin下调MITF、酪氨酸酶、TRP-1和Dct(TRP-2)的mRNA和蛋白质表达水平。Cajanin诱导细胞周期阻滞于G2/M期和S期。Cajanin刺激成骨细胞增殖。卡加宁有潜力研究人类色素沉着障碍和绝经期骨质疏松[1][2]。

名称

• 中文名: 2',4',5-三羟基-7-甲氧基异黄酮
• 英文名: 3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxychromen-4-one

生物活性

• 描述: 卡加宁是一种有效的口服活性抗黑素制剂。Cajanin在MNT1细胞中显示出抗增殖活性。木豆苷能有效降低黑色素含量。Cajanin下调MITF、酪氨酸酶、TRP-1和Dct(TRP-2)的mRNA和蛋白质表达水平。Cajanin诱导细胞周期阻滞于G2/M期和S期。Cajanin刺激成骨细胞增殖。卡加宁有潜力研究人类色素沉着障碍和绝经期骨质疏松[1][2]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 体外研究: Cajanin对成骨细胞有较强的促有丝分裂和促分化作用[2]。Cajanin诱导Erk1/2和Akt的磷酸化[2]。
• 体内研究: Cajanin(10 mg/kg,p.o.；连续30天每天)可提高Sprague-Dawley大鼠骨骼所有解剖区域的骨密度水平[1]。
• 参考文献:

  [1]. Netcharoensirisuk P, et al. Cajanin Suppresses Melanin Synthesis through Modulating MITF in Human Melanin-Producing Cells. Molecules. 2021 Oct 5;26(19):6040.

  [2]. Bhargavan B, et al. Methoxylated isoflavones, cajanin and isoformononetin, have non-estrogenic bone forming effect via differential mitogen activated protein kinase (MAPK) signaling. J Cell Biochem. 2009 Oct 1;108(2):388-99.

  [3]. Wensaas AJ, et al. Fatty acid incubation of myotubes from humans with type 2 diabetes leads to enhanced release of beta-oxidation products because of impaired fatty acid oxidation: effects of tetradecylthioacetic acid and eicosapentaenoic acid. Diabetes. 2009 Mar;58(3):527-35.

物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 605.5±55.0 °C at 760 mmHg
• 分子式: C₁₆H₁₂O₆
• 分子量: 300.263
• 闪点: 231.7±25.0 °C
• 精确质量: 300.063385
• PSA: 100.13000
• LogP: 3.57
• InChIKey: ALFNTRJPGFNJQV-UHFFFAOYSA-N
• SMILES: COc1cc(O)c2c(=O)c(-c3ccc(O)cc3O)coc2c1
• 外观性状: 黄色粉末
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.697
• 储存条件: 室温

安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2914509090

海关

• 海关编码: 2914509090
• 中文概述: 2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 丙酮报明包装
• Summary: HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

靶点实验

查看更多实验

实验名称：Antimicrobial activity against Staphylococcus aureus DSM 799 at 1 ug/ul after 24 hrs ... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL1693932

实验名称：Antimicrobial activity against Klebsiella pneumoniae DSM 681 at 1 ug/ul after 24 hrs ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL1693933

实验名称：Antimicrobial activity against Pseudomonas aeruginosa DSM 1128 at 1 ug/ul after 24 hr... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL1693934

实验名称：Antimicrobial activity against Escherichia coli DSM 682 after 24 hrs by disk diffusio... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL1693935

实验名称：Antioxidant activity assessed as DPPH radical scavenging activity at 5 ug 来源：ChEMBL 靶标：N/A External Id：CHEMBL1006063

实验名称：Antifungal activity against Aspergillus niger DSM 1988 after 48 hrs by disk diffusion... 来源：ChEMBL 靶标：Aspergillus niger External Id：CHEMBL1693936

实验名称：Antioxidant activity assessed as DPPH radical scavenging activity at 1 ug 来源：ChEMBL 靶标：N/A External Id：CHEMBL1006064

实验名称：Antifungal activity against Candida albicans DSM 1386 after 24 hrs by disk diffusion ... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL1693937

实验名称：Induction of mineralization in Sprague-Dawley rat calvaria derived primary osteoblast... 来源：ChEMBL 靶标：Osteoblast External Id：CHEMBL1023758

实验名称：Antifungal activity against Candida albicans at 5 ug after 3 days by MTT assay 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL1006061

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英文别名

• 5,2',4'-Trihydroxy-7-methoxyisoflavone
• Cajanin
• 2',4',5-Trihydroxy-7-methoxyisoflavon
• 3-(2,4-Dihydroxyphenyl)-5-hydroxy-7-methoxy-4H-chromen-4-one
• 2',4',5-trihydroxy-7-methoxyisoflavone