DZ2002

• 常用名: DZ2002
• 英文名: DZ2002
• CAS号: 33231-14-0
• 分子量: 251.24200
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₀H₁₃N₅O₃
• 熔点: N/A
• 闪点: N/A

DZ2002用途

DZ2002是腺苷同型半胱氨酸水解酶(SAHH; AdoHcy Hydrolase)高效可逆性抑制剂,Ki值为17.9nM。

DZ2002名称

• 中文名: DZ2002
• 英文名: (rac)-DZ2002

DZ2002生物活性

• 描述: DZ2002是腺苷同型半胱氨酸水解酶(SAHH; AdoHcy Hydrolase)高效可逆性抑制剂,Ki值为17.9nM。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Wu QL, et al. Inhibition of S-adenosyl-L-homocysteine hydrolase induces immunosuppression. J Pharmacol Exp Ther. 2005 May;313(2):705-11.

  [2]. Fu YF, et al. S-adenosyl-L-homocysteine hydrolase inactivation curtails ovalbumin-induced immune responses. J Pharmacol Exp Ther. 2006 Mar;316(3):1229-37.

  [3]. He SJ, et al. Therapeutic effects of DZ2002, a reversible SAHH inhibitor, on lupus-prone NZB×NZW F1 mice via interference with TLR-mediated APC response. Acta Pharmacol Sin. 2014 Feb;35(2):219-29.

DZ2002物理化学性质

• 分子式: C₁₀H₁₃N₅O₃
• 分子量: 251.24200
• 精确质量: 251.10200
• PSA: 116.15000
• InChIKey: HNKGMGPCSSJYOT-UHFFFAOYSA-N
• SMILES: COC(=O)C(O)CCn1cnc2c(N)ncnc21
• 储存条件: 2-8℃

DZ2002靶点实验

查看更多实验

实验名称：Antiparasitic activity against Trichomonas vaginalis T1 at 10 uL after 24 hrs by hemo... 来源：ChEMBL 靶标：Trichomonas vaginalis External Id：CHEMBL1291163

实验名称：Immunosuppressive activity in BALB/c mouse splenic lymphocytes co-cultured with C57BL... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL992533

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DZ2002英文别名

• DZ2002
• methyl 4-(Adenin-9-yl)-2-hydroxybutanoate
• methyl 4-(adenin-9-yl)-2-hydroxybutanoate
• 4-(6-aminopurin-9-yl)-2-hydroxybutyric acid methyl ester
• 4-(6-amino-purin-9-yl)-2-hydroxy-butyric acid methyl ester
• 4-(6-Amino-purin-9-yl)-2-hydroxy-butyric acid methyl ester