槲皮素3,4'-二甲醚; 5,7,3'-三羟基-3,4'-二甲氧基黄酮

• 常用名: 槲皮素3,4'-二甲醚; 5,7,3'-三羟基-3,4'-二甲氧基黄酮
• 英文名: Quercetin 3,4'-dimethyl ether
• CAS号: 33429-83-3
• 分子量: 330.29
• 密度: 1.6±0.1 g/cm3
• 沸点: 607.0±55.0 °C at 760 mmHg
• 分子式: C₁₇H₁₄O₇
• 熔点: 229-230ºC
• 闪点: 227.3±25.0 °C

用途

Quercetin 3,4′-dimethyl ether (3,4′-Dimethylquercetin) 是一种可以从 Combretum quadrangulare 中分离得到的二甲氧基黄酮。Quercetin 3,4′-dimethyl ether? 通过增强DR5表达来克服TRAIL抗性,具有抗肿瘤活性。

名称

• 中文名: 3',5,7-三羟基-3,4'-二甲氧基黄酮
• 英文名: 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3-methoxychromen-4-one
• 中文别名: 3’,5,7-三羟基-3,4’-二甲氧基黄酮

生物活性

• 描述: Quercetin 3,4′-dimethyl ether (3,4′-Dimethylquercetin) 是一种可以从 Combretum quadrangulare 中分离得到的二甲氧基黄酮。Quercetin 3,4′-dimethyl ether? 通过增强DR5表达来克服TRAIL抗性,具有抗肿瘤活性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Toume K, et al. Cycloartane triterpenes isolated from Combretum quadrangulare in a screening program for death-receptor expression enhancing activity. J Nat Prod. 2011 Feb 25;74(2):249-55.

物理化学性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 607.0±55.0 °C at 760 mmHg
• 熔点: 229-230ºC
• 分子式: C₁₇H₁₄O₇
• 分子量: 330.29
• 闪点: 227.3±25.0 °C
• 精确质量: 330.073944
• PSA: 109.36000
• LogP: 1.85
• InChIKey: ZSPZNFOLWQEVQJ-UHFFFAOYSA-N
• SMILES: COc1ccc(-c2oc3cc(O)cc(O)c3c(=O)c2OC)cc1O
• 外观性状: 黄色粉末
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.701
• 储存条件: 2-8℃，密封，干燥

安全信息

• 海关编码: 2914509090

海关

• 海关编码: 2914509090
• 中文概述: 2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 丙酮报明包装
• Summary: HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

靶点实验

查看更多实验

实验名称：Inhibition of recombinant human PTP-sigma (residues 1367 to 1948) using para-nitrophe... 来源：ChEMBL 靶标：Receptor-type tyrosine-protein phosphatase S External Id：CHEMBL3744703

实验名称：Cytotoxicity against TRAIL-resistant human AGS cells assessed as cell viability at 12... 来源：ChEMBL 靶标：AGS External Id：CHEMBL1693930

实验名称：Cytotoxicity against TRAIL-resistant human AGS cells assessed as cell viability at 17... 来源：ChEMBL 靶标：AGS External Id：CHEMBL1693931

实验名称：Anti-inflammatory activity in mouse BV-2 cells assessed as inhibition of LPS-induced ... 来源：ChEMBL 靶标：BV-2 External Id：CHEMBL5543296

实验名称：Inhibition of recombinant human PTP-sigma (residues 1367 to 1948) using para-nitrophe... 来源：ChEMBL 靶标：Receptor-type tyrosine-protein phosphatase S External Id：CHEMBL3744704

实验名称：In vitro cytotoxic potency against NCI-60 human tumor cell line 来源：ChEMBL 靶标：Panel NCI-60 (60 carcinoma cell lines) External Id：CHEMBL749609

实验名称：In vivo antitumor activity against mouse P388 cells 来源：ChEMBL 靶标：P388 External Id：CHEMBL1002694

实验名称：Increase in DR5 promoter activity in SacI gene expressing human DLD1 cells at 17.5 to... 来源：ChEMBL 靶标：Tumor necrosis factor receptor superfamily member 10B External Id：CHEMBL1693927

实验名称：Cytotoxicity against human KB cells 来源：ChEMBL 靶标：KB External Id：CHEMBL1002689

实验名称：HIV Cellular Data 来源：NIAID 靶标：N/A External Id：HIV Cellular Data

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英文别名

• 5,7,3'-Trihydroxy-3,4'-dimethoxyflavone
• 3',5,7-Trihydroxy-3',4'-dimethoxyflavone
• Quercetin 3,4'-dimethyl Ether
• 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3-methoxy-4H-chromen-4-one
• 3',5,7-Trihydroxy-3,4'-dimethoxyflavone
• quercetin-3,4'-dimethyl ether
• 3,4'-O-dimethylquercetin
• MFCD00016927
• 5,7-Dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)-3-methoxy-1-benzopyran-4-one
• 3',5,7-trihydroxy-3,4'-dimethoxy flavone, Quercetin 3,4'-dimethyl Ether
• 5,5,3'-trihydroxy-3,4'-dimethoxyflavone
• 3,4'-dimethoxy-5,7-3'-trihydroxyflavone