HPCG

• 常用名: HPCG
• 英文名: HPCG
• CAS号: 3458-69-3
• 分子量: 196.16000
• 密度: N/A
• 沸点: N/A
• 分子式: C₈H₈N₂O₄
• 熔点: N/A
• 闪点: N/A

HPCG用途

2-(3-羟基吡啶甲酰氨基)乙酸是一种2OG加氧酶抑制剂,IC50值为3.4μM。2-(3-羟基吡啶甲酰氨基)乙酸可以用作潜在治疗研究的功能探针[1]。

HPCG名称

• 英文名: N-[(3-Hydroxy-2-pyridinyl)carbonyl]glycine

HPCG生物活性

• 描述: 2-(3-羟基吡啶甲酰氨基)乙酸是一种2OG加氧酶抑制剂,IC50值为3.4μM。2-(3-羟基吡啶甲酰氨基)乙酸可以用作潜在治疗研究的功能探针[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> 组蛋白去甲基化酶
• 参考文献:

  [1]. Woon EC, et al. Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase. J Med Chem. 2012 Mar 8;55(5):2173-84.

HPCG物理化学性质

• 分子式: C₈H₈N₂O₄
• 分子量: 196.16000
• 精确质量: 196.04800
• PSA: 103.01000
• LogP: 0.17640
• InChIKey: IZQMRNMMPSNPJM-UHFFFAOYSA-N
• SMILES: O=C(O)CNC(=O)c1ncccc1O

HPCG靶点实验

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实验名称：Experimentally measured binding affinity data (IC50) for protein-ligand complexes der... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-IC50 for protein-ligand complexes

实验名称：Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia col... 来源：ChEMBL 靶标：Alpha-ketoglutarate-dependent dioxygenase FTO External Id：CHEMBL2344107

实验名称：Inhibition of Escherichia coli AlkB deltaN11 mutant using 5'-TTCmTTTTTTTTTTTT-3'-fluo... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2034755

实验名称：Inhibition of FTO (unknown origin) 来源：ChEMBL 靶标：Alpha-ketoglutarate-dependent dioxygenase FTO External Id：CHEMBL5229122

实验名称：Binding affinity to Escherichia coli AlkB deltaN11 mutant assessed as change in melti... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2034754

实验名称：ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301365

实验名称：Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO demet... 来源：ChEMBL 靶标：Alpha-ketoglutarate-dependent dioxygenase FTO External Id：CHEMBL5216101

实验名称：Inhibition of PHD2 at 1 mM by HTRF assay 来源：ChEMBL 靶标：Egl nine homolog 1 External Id：CHEMBL1260834

实验名称：Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia col... 来源：ChEMBL 靶标：Alpha-ketoglutarate-dependent dioxygenase FTO External Id：CHEMBL2344108

实验名称：ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301366

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HPCG英文别名

• HPCG