MIND4-17

• 常用名: MIND4-17
• 英文名: MIND4-17
• CAS号: 345989-24-4
• 分子量: 405.430
• 密度: 1.4±0.1 g/cm3
• 沸点: 667.5±65.0 °C at 760 mmHg
• 分子式: C₂₀H₁₅N₅O₃S
• 熔点: N/A
• 闪点: 357.5±34.3 °C

MIND4-17用途

NRF2诱导剂选择性激活NRF2信号传导,CD值(比活性加倍的浓度)为0.18 uM；共价修饰E3连接酶底物衔接蛋白KEAP1的关键应激传感器半胱氨酸(C151),阻止KEAP/NRF2复合物在活细胞中的闭合构象；有效抑制原代小鼠HD和WT小胶质细胞和星形胶质细胞中促炎细胞因子IL-6的释放。

MIND4-17名称

• 英文名: MIND4-17

MIND4-17生物活性

• 描述: NRF2诱导剂选择性激活NRF2信号传导,CD值(比活性加倍的浓度)为0.18 uM；共价修饰E3连接酶底物衔接蛋白KEAP1的关键应激传感器半胱氨酸(C151),阻止KEAP/NRF2复合物在活细胞中的闭合构象；有效抑制原代小鼠HD和WT小胶质细胞和星形胶质细胞中促炎细胞因子IL-6的释放。
• 参考文献: References 1. Quinti L, et al. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4676-E4685. View Related Products by Target Keap1-Nrf2

MIND4-17物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 667.5±65.0 °C at 760 mmHg
• 分子式: C₂₀H₁₅N₅O₃S
• 分子量: 405.430
• 闪点: 357.5±34.3 °C
• 精确质量: 405.089569
• LogP: 5.49
• InChIKey: OZUBDKIROJPQGE-UHFFFAOYSA-N
• SMILES: O=[N+]([O-])c1ccc(Sc2nnc(COc3ccccc3)n2-c2ccccc2)nc1
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.698

MIND4-17靶点实验

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实验名称：qHTS screening for TAG (triacylglycerol) accumulators in algae 来源：11812 靶标：N/A External Id：FATTTLab-Algae-Lipid

实验名称：Biochemical Deacetylation Assay from US Patent US9737525: "Small molecule activators ... 来源：BindingDB 靶标：N/A External Id：BindingDB_1678_1

实验名称：Induction of NQO1 expression in mouse Hepa1c1c7 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL5528628

实验名称：Inhibitors of CDC25B-CDK2/CyclinA interaction 来源：Center for Chemical Genomics, University of Michigan External Id：MScreen:TargetID_600

实验名称：Alphascreen assay for small molecules abrogating mHTT-CaM Interaction 来源：24983 靶标：Huntingtin External Id：KUHTS-Muma KU-CaM-Htt INH-01

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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MIND4-17英文别名

• MIND4-17
• 5-Nitro-2-{[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}pyridine
• 5-nitro-2-{[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thio}pyridine
• MFCD01899657