MIND4-17
Modify Date: 2024-01-16 19:23:53
MIND4-17 structure
|
Common Name | MIND4-17 | ||
|---|---|---|---|---|
| CAS Number | 345989-24-4 | Molecular Weight | 405.430 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 667.5±65.0 °C at 760 mmHg | |
| Molecular Formula | C20H15N5O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 357.5±34.3 °C | |
Use of MIND4-17An inducer of NRF2 that selectively activates NRF2 signaling with CD value (The concentration that doubles the specific activity) of 0.18 uM; covalently modifies a critical stress-sensor cysteine (C151) of the E3 ligase substrate adaptor protein KEAP1, arrests KEAP/NRF2 complex in the closed conformation in live cells; potently represses the release of the proinflammatory cytokine IL-6 in primary mouse HD and WT microglia and astrocytes. |
| Name | MIND4-17 |
|---|---|
| Synonym | More Synonyms |
| Description | An inducer of NRF2 that selectively activates NRF2 signaling with CD value (The concentration that doubles the specific activity) of 0.18 uM; covalently modifies a critical stress-sensor cysteine (C151) of the E3 ligase substrate adaptor protein KEAP1, arrests KEAP/NRF2 complex in the closed conformation in live cells; potently represses the release of the proinflammatory cytokine IL-6 in primary mouse HD and WT microglia and astrocytes. |
|---|---|
| References | References 1. Quinti L, et al. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4676-E4685. View Related Products by Target Keap1-Nrf2 |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 667.5±65.0 °C at 760 mmHg |
| Molecular Formula | C20H15N5O3S |
| Molecular Weight | 405.430 |
| Flash Point | 357.5±34.3 °C |
| Exact Mass | 405.089569 |
| LogP | 5.49 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.698 |
| MIND4-17 |
| 5-Nitro-2-{[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}pyridine |
| 5-nitro-2-{[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thio}pyridine |
| Pyridine, 5-nitro-2-[[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thio]- |
| MFCD01899657 |