TGX-155

• 常用名: TGX-155
• 英文名: TGX-155
• CAS号: 351071-90-4
• 分子量: 354.37
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₉FN₂O₃
• 熔点: N/A
• 闪点: N/A

TGX-155用途

TGX-155(AZ12649385)是PI3Kβ的选择性抑制剂。TGX-155在抗血栓治疗中具有潜在的应用[1][2][3]。

TGX-155名称

• 英文名: 8-(4-fluoro-2-methylphenoxy)-2-morpholin-4-yl-1H-quinolin-4-one

TGX-155生物活性

• 描述: TGX-155(AZ12649385)是PI3Kβ的选择性抑制剂。TGX-155在抗血栓治疗中具有潜在的应用[1][2][3]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> PI3K
• 靶点实验:

  PI3Kβ

• 体内研究: TGX-155(1.5 mg/kg和 2.5毫克/千克静脉注射；单剂量) 以时间和剂量依赖性方式显著改善了兔颈动脉损伤中的循环血流量减少 (CFRs)[3]
• 参考文献:

  [1]. Verheijen J C, et al. Phosphatidylinositol 3-kinase (PI3K) inhibitors as anticancer drugs[J]. Drugs Future, 2007, 32(6): 537-547.

  [2]. Nylander S, et al. Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor. J Thromb Haemost. 2012 Oct;10(10):2127-36.

  [3]. Sturgeon SA, et al. Adaptation of the Folts and electrolytic methods of arterial thrombosis for the study of anti-thrombotic molecules in small animals. J Pharmacol Toxicol Methods. 2006 Jan-Feb;53(1):20-9.

TGX-155物理化学性质

• 分子式: C₂₀H₁₉FN₂O₃
• 分子量: 354.37
• 精确质量: 354.13800
• PSA: 54.82000
• LogP: 4.08180
• InChIKey: FZTZVNFKDPBYKA-UHFFFAOYSA-N
• SMILES: Cc1cc(F)ccc1Oc1cccc2c(=O)cc(N3CCOCC3)[nH]c12

TGX-155靶点实验

查看更多实验

实验名称：Inhibition of recombinant human PI3Kbeta using PIP2 as substrate preincubated for 20 ... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform External Id：CHEMBL5682773

实验名称：Inhibition of N-terminus poly-His tagged human PI3Kalpha expressed in baculovirus inf... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform External Id：CHEMBL2067455

实验名称：Inhibition of N-terminus poly-His tagged human PI3Kgamma expressed in baculovirus inf... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform External Id：CHEMBL2067458

实验名称：Inhibition of recombinant human PI3Kalpha using PIP2 as substrate preincubated for 20... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform External Id：CHEMBL5682776

实验名称：Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infe... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform External Id：CHEMBL2067456

实验名称：Inhibition of poly-His tagged human PI3Kdelta expressed in baculovirus infected insec... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform External Id：CHEMBL2067457

实验名称：Inhibition of PI3Kgamma (unknown origin) assessed as decrease in fluorescence intensi... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform External Id：CHEMBL3366680

实验名称：ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301365

实验名称：ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301367

实验名称：Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform External Id：CHEMBL2066371

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TGX-155英文别名

• tgx-155