Ac-Arg-Cys-Met-5-aminopentanoyl-Arg-Val-Tyr-5-aminopentanoyl-Cys-NH2 trifluoroacetate salt (Disulfide bond)

• 常用名: Ac-Arg-Cys-Met-5-aminopentanoyl-Arg-Val-Tyr-5-aminopentanoyl-Cys-NH2 trifluoroacetate salt (Disulfide bond)
• 英文名: Ac-Arg-Cys-Met-5-aminopentanoyl-Arg-Val-Tyr-5-aminopentanoyl-Cys-NH2 trifluoroacetate salt (Disulfide bond)
• CAS号: 353487-64-6
• 分子量: 1167.471
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₄₉H₈₂N₁₆O₁₁S₃
• 熔点: N/A
• 闪点: N/A

用途

hMCH-1R拮抗剂1(化合物30)是具有3.6nM的KB值的人黑色素浓缩激素受体1(hMCHR1)的有效且选择性的拮抗剂。HMCH-1R拮抗剂1可以分别以65nM和49nM的IC50值与hMCHR1和hMCHR2结合。HMCH-1R拮抗剂1可用于代谢研究[1]。

名称

• 英文名: Ac-Arg-Cys-Met-5-aminopentanoyl-Arg-Val-Tyr-5-aminopentanoyl-Cys-NH2 trifluoroacetate salt (Disulfide bond)

生物活性

• 描述: hMCH-1R拮抗剂1(化合物30)是具有3.6nM的KB值的人黑色素浓缩激素受体1(hMCHR1)的有效且选择性的拮抗剂。HMCH-1R拮抗剂1可以分别以65nM和49nM的IC50值与hMCHR1和hMCHR2结合。HMCH-1R拮抗剂1可用于代谢研究[1]。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> MCHR1(GPR24)
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Bednarek MA, et al. Synthesis and biological evaluation in vitro of selective, high affinity peptide antagonists of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. Biochemistry. 2002 May 21;41(20):6383-90.

物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₄₉H₈₂N₁₆O₁₁S₃
• 分子量: 1167.471
• 精确质量: 1166.551147
• LogP: -4.43
• 折射率: 1.663

英文别名

• (4R,13S,16S,19S,28S,31R)-31-[(N2-Acetyl-L-arginyl)amino]-19-(3-carbamimidamidopropyl)-13-(4-hydroxybenzyl)-16-isopropyl-28-[2-(methylsulfanyl)ethyl]-6,12,15,18,21,27,30-heptaoxo-1,2-dithia-5,11,14,1 7,20,26,29-heptaazacyclodotriacontane-4-carboxamide
• 1,2-Dithia-5,11,14,17,20,26,29-heptaazacyclodotriacontane-4-carboxamide, 31-[[(2S)-2-(acetylamino)-5-[(aminoiminomethyl)amino]-1-oxopentyl]amino]-19-[3-[(aminoiminomethyl)amino]propyl]-13-[(4-hydroxyphenyl)methyl]-16-(1-methylethyl)-28-[2-(methylthio)ethyl]-6,12,15,18,21,27,30-heptaoxo-, (4R,13S,16S,19S,28S,31R)-