Endochin

• 常用名: Endochin
• 英文名: Endochin
• CAS号: 354155-51-4
• 分子量: 287.40
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₂₅NO₂
• 熔点: N/A
• 闪点: N/A

Endochin用途

内分泌是一种抗疟药。内分泌抑制弓形虫的IC50为0.003 nM。内分泌对实验性弓形虫病也有活性[1][2]。

Endochin名称

• 英文名: Endochin

Endochin生物活性

• 描述: 内分泌是一种抗疟药。内分泌抑制弓形虫的IC50为0.003 nM。内分泌对实验性弓形虫病也有活性[1][2]。
• 相关类别:
  研究领域 >> 感染
• 体外研究: 内分泌抑制弓形虫细胞色素 公元前1年复合物对细胞色素 c的还原,IC50为 8.2纳米[1]内分泌抑制 弓形虫的 IC50为 0.003纳米[1]内分泌(化合物1)抑制 恶性疟原虫分离出的多重耐药 W2型和 TM90-C2B型分离株,IC50分别为 8.59和 46.6毫摩尔[2]
• 参考文献:

  [1]. Doggett JS, et al. Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis. Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15936-41.

  [2]. Cross RM, et al. Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity. J Med Chem. 2010 Oct 14;53(19):7076-94.

Endochin物理化学性质

• 分子式: C₁₈H₂₅NO₂
• 分子量: 287.40

Endochin靶点实验

查看更多实验

实验名称：Antiparasitic activity against Toxoplasma gondii infected in HFF cells incubated for ... 来源：ChEMBL 靶标：Toxoplasma gondii External Id：CHEMBL5232742

实验名称：ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania ... 来源：ChEMBL 靶标：Glucose transporter External Id：CHEMBL3436044

实验名称：Resistant index. ratio of EC50 for chloroquine, mefloquine, pyrimethamine and atovaqu... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL1261024

实验名称：Antimalarial activity against chloroquine, mefloquine, pyrimethamine and atovaquone-r... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL1261023

实验名称：ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania ... 来源：ChEMBL 靶标：Solute carrier family 2, facilitated glucose transporter member 1 External Id：CHEMBL3436042

实验名称：ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania ... 来源：ChEMBL 靶标：Hexose transporter 1 External Id：CHEMBL3436043

实验名称：Antiplasmodial activity against Plasmodium falciparum Dd2 infected in human Erythrocy... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL5244557

实验名称：Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 MRA-285 ... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL3266493

实验名称：Half life in mouse liver microsomes 来源：ChEMBL 靶标：N/A External Id：CHEMBL1261032

实验名称：Passive transcellular permeability of the compound at pH 4 by PAMPA 来源：ChEMBL 靶标：N/A External Id：CHEMBL1261031

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