3A,4,5,9b-四氢-3H-环戊并[c]喹啉-4-羧酸

• 常用名: 3A,4,5,9b-四氢-3H-环戊并[c]喹啉-4-羧酸
• 英文名: MurA-IN-1
• CAS号: 354815-90-0
• 分子量: 215.25
• 密度: 1.25g/cm3
• 沸点: 406.5ºC at 760 mmHg
• 分子式: C₁₃H₁₃NO₂
• 熔点: N/A
• 闪点: 199.7ºC
• 符号: GHS06
• 信号词: Danger

3A,4,5,9b-四氢-3H-环戊并[c]喹啉-4-羧酸用途

MurA-IN-1(化合物1a)是一种PTPRR抑制剂,PTP1B、PTPN5、PTPN7和PTPRR的IC50值分别为0.23μM、0.8μM、0.75μM和0.09μM[1]。(人类MAPK特异性蛋白酪氨酸磷酸酶家族)

3A,4,5,9b-四氢-3H-环戊并[c]喹啉-4-羧酸名称

• 中文名: 3A,4,5,9b-四氢-3H-环戊并[c]喹啉-4-羧酸
• 英文名: 3a,4,5,9b-tetrahydro-3h-cyclopenta[c]quinoline-4-carboxylic acid

3A,4,5,9b-四氢-3H-环戊并[c]喹啉-4-羧酸生物活性

• 描述: MurA-IN-1(化合物1a)是一种PTPRR抑制剂,PTP1B、PTPN5、PTPN7和PTPRR的IC50值分别为0.23μM、0.8μM、0.75μM和0.09μM[1]。(人类MAPK特异性蛋白酪氨酸磷酸酶家族)
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 靶点实验:

  IC50: 0.23 μM (PTP1B), 0.8 μM (PTPN5), 0.75 μM (PTPN7), 0.09 μM (PTPRR)[1].

• 参考文献:

  [1]. Jeyanthy Eswaran, et al. Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases. Biochem J. 2006 May 1;395(3):483-91.

3A,4,5,9b-四氢-3H-环戊并[c]喹啉-4-羧酸物理化学性质

• 密度: 1.25g/cm3
• 沸点: 406.5ºC at 760 mmHg
• 分子式: C₁₃H₁₃NO₂
• 分子量: 215.25
• 闪点: 199.7ºC
• 精确质量: 215.09500
• PSA: 49.33000
• LogP: 2.36300
• InChIKey: WRJCENKZISEXPF-UHFFFAOYSA-N
• SMILES: O=C(O)C1Nc2ccccc2C2C=CCC12
• 折射率: 1.606

3A,4,5,9b-四氢-3H-环戊并[c]喹啉-4-羧酸安全信息

• 符号: GHS06
• 信号词: Danger
• 危害声明: H301
• 警示性声明: P301 + P310
• 危害码 (欧洲): Xi
• 危险品运输编码: UN 2811 6.1 / PGIII
• 海关编码: 2933990090

3A,4,5,9b-四氢-3H-环戊并[c]喹啉-4-羧酸海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3A,4,5,9b-四氢-3H-环戊并[c]喹啉-4-羧酸靶点实验

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